Translocation t(8;13)(p11;q11‐12) in stem cell leukemia/lymphoma of t‐cell and myeloid lineages

Rizwan Naeem, Samuel Singer, Jonathan A. Fletcher

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

An unusual hematologic neoplasia has been described recently in which the predominant clinical features include T‐cell lymphoma, myeloid hyperplasia, and eosinophilia. The multilineage involvement in this disorder suggests transformation of a primitive stem cell. Abnormal karyotypes have been described in three such cases, including one case with t(8;13)(p11.2;q12) and a second case with t(8;13)(p23;q14). We report translocation of chromosomes 8 and 13 in lymph node karyotypes from two patients with this syndrome. Fluorescence in situ hybridization confirmed an identical translocation, t(8;13)(p11;q11‐12), in lymphoma cells from each patient. The translocation breakpoints are of particular interest because the FLT3 receptor tyrosine kinase gene has been mapped to 13q12. FLT3 is expressed highly in hematopoietic progenitor cells and in myeloid and lymphoid acute leukemias.

Original languageEnglish (US)
Pages (from-to)148-151
Number of pages4
JournalGenes, Chromosomes and Cancer
Volume12
Issue number2
DOIs
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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