Translocation of oncogene c-sis from chromosome 22 to chromosome 17 in a human myelogenous leukemia cell line

Pasquale Tripputi, Linda A. Cannizzaro, James Kuo, Daniela Biassoni, Gianmarco Corneo

Research output: Contribution to journalArticle

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Abstract

By combining somatic cell genetics, in situ hybridization and Southern hybridization, we found that the c-sis oncogene in the human myelogenous leukemia cell line ML3is translocated from the long arm (q 11 →qter) of chromosome 22 to the long arm (mid-portion or q21 region) of chromosome 17. This translocation does not result in rearrangement of the c-sis oncogene.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalActa Haematologica
Volume77
Issue number3
DOIs
Publication statusPublished - Jan 1 1987

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Keywords

  • Chromosomal translocation
  • Hybridization
  • In situ
  • Somatic cell hybrids

ASJC Scopus subject areas

  • Hematology

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