Translocation (5; 11) in a conjunctival MALT lymphoma

Cecilia G. Clement; Venkateswara R. Potluri; John Gonzales; You Wen Qian

Translocation (5; 11) in a conjunctival MALT lymphoma

Cecilia G. Clement, Venkateswara R. Potluri, John Gonzales, You Wen Qian

Research output: Contribution to journal › Article › peer-review

Abstract

Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lymphomas and ocular MALT lymphomas as well.

Original language	English (US)
Pages (from-to)	722-726
Number of pages	5
Journal	International Journal of Clinical and Experimental Pathology
Volume	4
Issue number	7
State	Published - 2011
Externally published	Yes

Keywords

Conjunctiva
MALT lymphoma
Ocular
Translocation

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

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abstract = "Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lymphomas and ocular MALT lymphomas as well.",

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AU - Clement, Cecilia G.

AU - Potluri, Venkateswara R.

AU - Gonzales, John

AU - Qian, You Wen

PY - 2011

Y1 - 2011

N2 - Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lymphomas and ocular MALT lymphomas as well.

AB - Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lymphomas and ocular MALT lymphomas as well.

KW - Conjunctiva

KW - MALT lymphoma

KW - Ocular

KW - Translocation

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Translocation (5; 11) in a conjunctival MALT lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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