Translocation (2;9)(p12;p23) in a case of acute leukemia with t(4;11)(q21;q23). Lack of rearrangement of the kappa and interferon gene loci

Elisabeth M. Paietta, Brian Van Ness, Michelle M. Le Beau, John Bennett, Peter Cassileth, Peter H. Wiernik

Research output: Contribution to journalArticle

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Abstract

A case is reported of an adult male patient with acute leukemia characterized by the presence of the novel cytogenetic abnormality, t(2;9)(p12;p23), in addition to a t(4;11)(q21;q23). The immunophenotype of the blast cell population was consistent with immature early pre-B cell acute lymphoblastic leukemia (ALL) (TdT+,HLA-DR+,CD19+,CD24±,CD10-) expressing myelo-monocytic antigens (CDw65,CD15). The genotype showed a clonal rearrangement of the immunoglobulin heavy chain locus. Because the immunoglobulin kappa (κ) light chain gene is located on chromosome 2 at band p12 and interferon alpha (α) and beta (β) map to chromosome 9p21-p22, rearrangements of these loci as a result of the t(2;9) were studied. There was no evidence for rearrangement of the region covering about 40 kilobases around the κ locus when hybridized to C(κ), the 3′ κ enhancer or the κ deleting element. Only germline size restriction fragments were also found for the interferon α and β genes. The patient's clinical features were typical for ALL associated with the t(4;11), including a high white blood cell count at presentation, hepatosplenomegaly, and a poor outcome. The potential significance of 2p and 9p abnormalities in addition to t(4;11) is discussed.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume60
Issue number1
DOIs
StatePublished - 1992

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Immunoglobulin Light Chain Genes
CD15 Antigens
Immunoglobulin Heavy Chains
B-Lymphoid Precursor Cells
Chromosomes, Human, Pair 2
Interferon-beta
HLA-DR Antigens
Leukocyte Count
Interferon-alpha
Chromosome Aberrations
Interferons
Genes
Chromosomes
Genotype
Population
interferon kappa
Human CDw65 antigen

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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Translocation (2;9)(p12;p23) in a case of acute leukemia with t(4;11)(q21;q23). Lack of rearrangement of the kappa and interferon gene loci. / Paietta, Elisabeth M.; Van Ness, Brian; Le Beau, Michelle M.; Bennett, John; Cassileth, Peter; Wiernik, Peter H.

In: Cancer Genetics and Cytogenetics, Vol. 60, No. 1, 1992, p. 82-85.

Research output: Contribution to journalArticle

Paietta, Elisabeth M. ; Van Ness, Brian ; Le Beau, Michelle M. ; Bennett, John ; Cassileth, Peter ; Wiernik, Peter H. / Translocation (2;9)(p12;p23) in a case of acute leukemia with t(4;11)(q21;q23). Lack of rearrangement of the kappa and interferon gene loci. In: Cancer Genetics and Cytogenetics. 1992 ; Vol. 60, No. 1. pp. 82-85.
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