Translational regulation as a novel mechanism for the development of cellular drug resistance

John C. Schmitz, Jun Liu, Xiukun Lin, Tian Min Chen, Wu Yan, Ningwen Tai, Ashwin Gollerkeri, Edward Chu

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalCancer and Metastasis Reviews
Volume20
Issue number1-2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Dihydrofolate reductase
  • Drug resistance
  • p53 translational regulation
  • Thymidylate synthase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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