Translational regulation as a novel mechanism for the development of cellular drug resistance

John C. Schmitz; Jun Liu; Xiukun Lin; Tian Min Chen; Wu Yan; Ningwen Tai; Ashwin Gollerkeri; Edward Chu

doi:10.1023/A:1013100306315

Translational regulation as a novel mechanism for the development of cellular drug resistance

John C. Schmitz, Jun Liu, Xiukun Lin, Tian Min Chen, Wu Yan, Ningwen Tai, Ashwin Gollerkeri, Edward Chu

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Cancer and Metastasis Reviews
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1013100306315
State	Published - 2001
Externally published	Yes

Keywords

Dihydrofolate reductase
Drug resistance
Thymidylate synthase
p53 translational regulation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1013100306315

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abstract = "Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.",

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T1 - Translational regulation as a novel mechanism for the development of cellular drug resistance

AU - Schmitz, John C.

AU - Liu, Jun

AU - Lin, Xiukun

AU - Chen, Tian Min

AU - Yan, Wu

AU - Tai, Ningwen

AU - Gollerkeri, Ashwin

AU - Chu, Edward

PY - 2001

Y1 - 2001

N2 - Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

AB - Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

KW - Dihydrofolate reductase

KW - Drug resistance

KW - Thymidylate synthase

KW - p53 translational regulation

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VL - 20

SP - 33

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JO - Cancer and Metastasis Reviews

JF - Cancer and Metastasis Reviews

IS - 1-2

ER -

Translational regulation as a novel mechanism for the development of cellular drug resistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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