Translational control of auditory imprinting and structural plasticity by eIF2α

Gervasio Batista, Jennifer Leigh Johnson, Elena Dominguez, Mauro Costa-Mattioli, Jose L. Pena

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2α) bidirectionally regulates auditory but not visual imprinting and related changes in structural plasticity in chickens. Increasing phosphorylation of eIF2α (p-eIF2α) reduces translation rates and spine plasticity, and selectively impairs auditory imprinting. By contrast, inhibition of an eIF2α kinase or blocking the translational program controlled by p-eIF2α enhances auditory imprinting. Importantly, these manipulations are able to reopen the critical period. Thus, we have identified a translational control mechanism that selectively underlies auditory imprinting. Restoring translational control of eIF2α holds the promise to rejuvenate adult brain plasticity and restore learning and memory in a variety of cognitive disorders.

Original languageEnglish (US)
Article numbere17197
JournaleLife
Volume5
Issue numberDECEMBER2016
DOIs
StatePublished - Dec 23 2016

Fingerprint

Prokaryotic Initiation Factor-2
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Plasticity
Phosphorylation
Data storage equipment
Labeling
Chickens
Brain
Spine
Phosphotransferases
Learning
Pharmacology
Imprinting (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Batista, G., Johnson, J. L., Dominguez, E., Costa-Mattioli, M., & Pena, J. L. (2016). Translational control of auditory imprinting and structural plasticity by eIF2α. eLife, 5(DECEMBER2016), [e17197]. https://doi.org/10.7554/eLife.17197

Translational control of auditory imprinting and structural plasticity by eIF2α. / Batista, Gervasio; Johnson, Jennifer Leigh; Dominguez, Elena; Costa-Mattioli, Mauro; Pena, Jose L.

In: eLife, Vol. 5, No. DECEMBER2016, e17197, 23.12.2016.

Research output: Contribution to journalArticle

Batista, G, Johnson, JL, Dominguez, E, Costa-Mattioli, M & Pena, JL 2016, 'Translational control of auditory imprinting and structural plasticity by eIF2α', eLife, vol. 5, no. DECEMBER2016, e17197. https://doi.org/10.7554/eLife.17197
Batista G, Johnson JL, Dominguez E, Costa-Mattioli M, Pena JL. Translational control of auditory imprinting and structural plasticity by eIF2α. eLife. 2016 Dec 23;5(DECEMBER2016). e17197. https://doi.org/10.7554/eLife.17197
Batista, Gervasio ; Johnson, Jennifer Leigh ; Dominguez, Elena ; Costa-Mattioli, Mauro ; Pena, Jose L. / Translational control of auditory imprinting and structural plasticity by eIF2α. In: eLife. 2016 ; Vol. 5, No. DECEMBER2016.
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