Transition-state structure of human 5′-methylthioadenosine phosphorylase

Medicine & Life Sciences

• 5'-methylthioadenosine phosphorylase 100%
• Isotopes 61%
• Kinetics 33%
• Carbon 15%
• 5'-methylthioadenosine 9%
• Density Functional Theory 8%
• Oxygen 7%
• Pemetrexed 6%
• Catalysis 6%
• Adenine 6%
• Sulfur 6%
• Phosphates 4%

Chemical Compounds

• Transition State Structure 71%
• Kinetic Isotope Effect 61%
• Transition State 30%
• Zwitterion 14%
• Isotope Effect 12%
• Nucleophile 10%
• Carbon Atom 8%
• Hyperconjugation 8%
• Bond Order 7%
• Dioxygen 6%
• Adenine 5%
• Ionization 4%
• Polarization 4%
• Phosphate 4%
• Catalysis 4%
• Density Functional Theory 3%

Engineering & Materials Science

• Isotopes 69%
• Nucleophiles 21%
• Carbon 11%
• Oxygen 8%
• Density functional theory 7%
• Catalysis 6%
• Ionization 6%
• Conformations 6%
• Phosphates 5%
• Sulfur 4%
• Polarization 4%