Transition state structure of 5′-methylthioadenosine/S- adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues

Medicine & Life Sciences

• adenosylhomocysteine nucleosidase 100%
• Isotopes 50%
• Kinetics 33%
• Escherichia coli 32%
• 5'-methylthioadenosine 9%
• Density Functional Theory 9%
• Ribose 7%
• Pemetrexed 6%
• Quorum Sensing 6%
• Catalysis 6%
• Polyamines 6%
• Adenine 6%
• Sulfur 6%
• Static Electricity 6%
• Drug Design 5%
• Carbon 5%
• Hydrolysis 4%
• Methylation 4%
• Ions 4%

Chemical Compounds

• Transition State Structure 59%
• Kinetic Isotope Effect 51%
• Transition State 25%
• Hyperconjugation 13%
• SN1 Mechanism 8%
• Ribose 5%
• Polyamine 5%
• Electrostatic Potential 5%
• Adenine 4%
• Nucleophile 4%
• pH Value 4%
• Dihedral Angle 4%
• Orbital 4%
• Pharmacological Metabolism 4%
• Antimicrobial Agent 3%
• Catalysis 3%
• Density Functional Theory 3%
• Hydrolysis 3%
• Carbon Atom 2%
• Ion 2%