Transition State Structure and Inhibition of Rv0091, a 5′-Deoxyadenosine/5′-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Medicine & Life Sciences

• adenosylhomocysteine nucleosidase 100%
• 5'-deoxyadenosine 87%
• 5'-methylthioadenosine phosphorylase 82%
• 5'-methylthioadenosine 82%
• Isotopes 50%
• S-Adenosylhomocysteine 48%
• Mycobacterium tuberculosis 45%
• Kinetics 33%
• Hydrolysis 28%
• Quorum Sensing 19%
• Polyamines 18%
• Adenine 18%
• Static Electricity 18%
• Substrate Specificity 17%
• Escherichia coli 10%
• Water 10%
• Enzymes 8%

Chemical Compounds

• Transition State Structure 59%
• Kinetic Isotope Effect 51%
• Hydrolysis 19%
• Bond Order 17%
• Homodimer 17%
• Polyamine 16%
• Electrostatic Potential 16%
• Adenine 14%
• Homogeneity 13%
• Nucleophile 13%
• Biosynthesis 13%
• Transition State 12%
• Surface 4%