Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a

Chemical Compounds

• Nucleophilic Aromatic Substitution 69%
• Meisenheimer Rearrangement 54%
• Glutathione 50%
• Transition State 46%
• 1-fluoro-2,4-dinitrobenzene 29%
• Dinitrobenzene 28%
• 1-chloro-2,4-dinitrobenzene 27%
• Proton 24%
• Thiol Group 20%
• Site-Directed Mutagenesis 19%
• Nitro Group 19%
• Kinetics Type 17%
• Proton Transfer 16%
• Time 13%
• Rate Constant 12%
• Crystal Structure 9%

Medicine & Life Sciences

• 2,4-dinitrobenzene 100%
• Glutathione Transferase 60%
• Protons 24%
• Catalytic Domain 21%
• glutathione-trinitrobenzene complex 20%
• Dinitrobenzenes 13%
• Binding Sites 12%
• Dinitrofluorobenzene 12%
• Dinitrochlorobenzene 11%
• Sulfhydryl Compounds 8%
• Site-Directed Mutagenesis 8%
• Glutathione 7%
• Cats 6%
• Kinetics 5%
• Water 5%
• Enzymes 4%