The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.
|Original language||English (US)|
|Number of pages||2|
|Journal||Nucleic acids symposium series (2004)|
|Publication status||Published - 2007|
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