Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Gary B. Evans; Richard H. Furneaux; Peter M. Kelly; Vern L. Schramm; Peter C. Tyler

doi:10.1093/nass/nrm032

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Gary B. Evans, Richard H. Furneaux, Peter M. Kelly, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

Original language	English (US)
Pages (from-to)	63-64
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm032
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nass/nrm032

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abstract = "The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.",

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AU - Schramm, Vern L.

AU - Tyler, Peter C.

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PY - 2007

Y1 - 2007

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AB - The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

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Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Abstract

ASJC Scopus subject areas

UN SDGs

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