Transient worsening of optic neuropathy as a sequela of the jarisch-herxheimer reaction in the treatment of lyme disease

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Abstract

A 58-year-old woman developed neurologic and neuro-ophthalmologic manifestations of Lyme disease, including a radiculomyelitis, cranial neuritis and mild right optic neuropathy. Upon treatment with intravenous ceftriaxone a Jarisch-Herxheimer reaction occurred with encephalopathy, mild fever, worsening radiculomyelitis, and deterioration of her visual acuity. Intravenous methyl-prednisolone was given, and the visual acuity recovered over 72 hours. This case suggests that transient worsening of optic neuropathy can develop as a sequela of the Jarisch-Herxheimer reaction in the treatment of Lyme disease.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalJournal of Neuro-Ophthalmology
Volume14
Issue number2
StatePublished - 1994

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Optic Nerve Diseases
Lyme Disease
Visual Acuity
Neuritis
Ceftriaxone
Brain Diseases
Prednisolone
Nervous System
Fever
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

Cite this

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title = "Transient worsening of optic neuropathy as a sequela of the jarisch-herxheimer reaction in the treatment of lyme disease",
abstract = "A 58-year-old woman developed neurologic and neuro-ophthalmologic manifestations of Lyme disease, including a radiculomyelitis, cranial neuritis and mild right optic neuropathy. Upon treatment with intravenous ceftriaxone a Jarisch-Herxheimer reaction occurred with encephalopathy, mild fever, worsening radiculomyelitis, and deterioration of her visual acuity. Intravenous methyl-prednisolone was given, and the visual acuity recovered over 72 hours. This case suggests that transient worsening of optic neuropathy can develop as a sequela of the Jarisch-Herxheimer reaction in the treatment of Lyme disease.",
author = "Strominger, {Mitchell B.} and Slamovits, {Thomas L.} and Steven Herskovitz and Lipton, {Richard B.}",
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T1 - Transient worsening of optic neuropathy as a sequela of the jarisch-herxheimer reaction in the treatment of lyme disease

AU - Strominger, Mitchell B.

AU - Slamovits, Thomas L.

AU - Herskovitz, Steven

AU - Lipton, Richard B.

PY - 1994

Y1 - 1994

N2 - A 58-year-old woman developed neurologic and neuro-ophthalmologic manifestations of Lyme disease, including a radiculomyelitis, cranial neuritis and mild right optic neuropathy. Upon treatment with intravenous ceftriaxone a Jarisch-Herxheimer reaction occurred with encephalopathy, mild fever, worsening radiculomyelitis, and deterioration of her visual acuity. Intravenous methyl-prednisolone was given, and the visual acuity recovered over 72 hours. This case suggests that transient worsening of optic neuropathy can develop as a sequela of the Jarisch-Herxheimer reaction in the treatment of Lyme disease.

AB - A 58-year-old woman developed neurologic and neuro-ophthalmologic manifestations of Lyme disease, including a radiculomyelitis, cranial neuritis and mild right optic neuropathy. Upon treatment with intravenous ceftriaxone a Jarisch-Herxheimer reaction occurred with encephalopathy, mild fever, worsening radiculomyelitis, and deterioration of her visual acuity. Intravenous methyl-prednisolone was given, and the visual acuity recovered over 72 hours. This case suggests that transient worsening of optic neuropathy can develop as a sequela of the Jarisch-Herxheimer reaction in the treatment of Lyme disease.

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