Abstract
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use. The association of central diabetes insipidus (CDI) with lithium use is rare. We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI. To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently. Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed. This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.
Original language | English (US) |
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Pages (from-to) | 339-343 |
Number of pages | 5 |
Journal | American Journal of Nephrology |
Volume | 16 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1996 |
Keywords
- Bipolar disorder
- Central diabetes insipidus
- Lithium
- Nephrogenic diabetes insipidus
- Polyuria
- Vasopressin
ASJC Scopus subject areas
- Nephrology