Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use

Laurie Posner, Michele H. Mokrzycki

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11 Scopus citations


Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use. The association of central diabetes insipidus (CDI) with lithium use is rare. We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI. To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently. Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed. This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalAmerican Journal of Nephrology
Issue number4
Publication statusPublished - Jan 1 1996



  • Bipolar disorder
  • Central diabetes insipidus
  • Lithium
  • Nephrogenic diabetes insipidus
  • Polyuria
  • Vasopressin

ASJC Scopus subject areas

  • Nephrology

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