TY - JOUR
T1 - Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
AU - Lang, Richard A.
AU - Metcalf, Donald
AU - Cuthbertson, R. Andrew
AU - Lyons, Ian
AU - Stanley, Ed
AU - Kelso, Anne
AU - Kannourakis, George
AU - Williamson, D. James
AU - Klintworth, Gordon K.
AU - Gonda, Thomas J.
AU - Dunn, Ashley R.
N1 - Funding Information:
This work was supported in part by the Anti-Cancer Council of Victoria, the National Health and Medical Research Fund of Canberra and the National Institutes of Health grant nos. 25972 and 22556. R. A. C. is a recipient of a National Health and Medical Research Council (Australia) Postdoctoral Fellowship. R. A. L. was supported in part by a Commonwealth Postgraduate Research Award.
PY - 1987/11/20
Y1 - 1987/11/20
N2 - Transgenic mice carrying the murine granulocyte-macrophage colony stimulating factor (GM-CSF) gene expressed from a retroviral promoter exhibit elevated levels of GM-CSF in the serum, urine, peritoneal cavity, and eye. The eyes of transgenic mice are opaque, contain accumulations of macrophages, and develop retinal damage. Similarly, lesions containing macrophages develop in striated muscle. The mice also display an accumulation of large, often multinucleate, activated macrophages in the peritoneal and pleural cavities. The transgene is transcribed in peritoneal cells, as well as in eyes and infiltrated striated muscle. A high proportion of transgenic mice die with muscle wasting when aged 2-4 months, possibly because of macrophage activation resulting from the high levels of GM-CSF.
AB - Transgenic mice carrying the murine granulocyte-macrophage colony stimulating factor (GM-CSF) gene expressed from a retroviral promoter exhibit elevated levels of GM-CSF in the serum, urine, peritoneal cavity, and eye. The eyes of transgenic mice are opaque, contain accumulations of macrophages, and develop retinal damage. Similarly, lesions containing macrophages develop in striated muscle. The mice also display an accumulation of large, often multinucleate, activated macrophages in the peritoneal and pleural cavities. The transgene is transcribed in peritoneal cells, as well as in eyes and infiltrated striated muscle. A high proportion of transgenic mice die with muscle wasting when aged 2-4 months, possibly because of macrophage activation resulting from the high levels of GM-CSF.
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U2 - 10.1016/0092-8674(87)90136-X
DO - 10.1016/0092-8674(87)90136-X
M3 - Article
C2 - 3499986
AN - SCOPUS:0023482090
VL - 51
SP - 675
EP - 686
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -