Transfusion-related immunomodulation: Review of the literature and implications for pediatric critical illness

Jennifer A. Muszynski, Philip C. Spinella, Jill M. Cholette, Jason P. Acker, Mark W. Hall, Nicole P. Juffermans, Daniel P. Kelly, Neil Blumberg, Kathleen Nicol, Jennifer L. Liedel, Allan Doctor, Kenneth E. Remy, Marisa Tucci, Jacques Lacroix, Philip J. Norris

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Transfusion-related immunomodulation (TRIM) in the intensive care unit (ICU) is difficult to define and likely represents a complicated set of physiologic responses to transfusion, including both proinflammatory and immunosuppressive effects. Similarly, the immunologic response to critical illness in both adults and children is highly complex and is characterized by both acute inflammation and acquired immune suppression. How transfusion may contribute to or perpetuate these phenotypes in the ICU is poorly understood, despite the fact that transfusion is common in critically ill patients. Both hyperinflammation and severe immune suppression are associated with poor outcomes from critical illness, underscoring the need to understand potential immunologic consequences of blood product transfusion. In this review we outline the dynamic immunologic response to critical illness, provide clinical evidence in support of immunomodulatory effects of blood product transfusion, review preclinical and translational studies to date of TRIM, and provide insight into future research directions.

Original languageEnglish (US)
JournalTransfusion
DOIs
StateAccepted/In press - 2016

Fingerprint

Immunomodulation
Critical Illness
Pediatrics
Blood Transfusion
Intensive Care Units
Immunosuppressive Agents
Inflammation
Phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Muszynski, J. A., Spinella, P. C., Cholette, J. M., Acker, J. P., Hall, M. W., Juffermans, N. P., ... Norris, P. J. (Accepted/In press). Transfusion-related immunomodulation: Review of the literature and implications for pediatric critical illness. Transfusion. https://doi.org/10.1111/trf.13855

Transfusion-related immunomodulation : Review of the literature and implications for pediatric critical illness. / Muszynski, Jennifer A.; Spinella, Philip C.; Cholette, Jill M.; Acker, Jason P.; Hall, Mark W.; Juffermans, Nicole P.; Kelly, Daniel P.; Blumberg, Neil; Nicol, Kathleen; Liedel, Jennifer L.; Doctor, Allan; Remy, Kenneth E.; Tucci, Marisa; Lacroix, Jacques; Norris, Philip J.

In: Transfusion, 2016.

Research output: Contribution to journalArticle

Muszynski, JA, Spinella, PC, Cholette, JM, Acker, JP, Hall, MW, Juffermans, NP, Kelly, DP, Blumberg, N, Nicol, K, Liedel, JL, Doctor, A, Remy, KE, Tucci, M, Lacroix, J & Norris, PJ 2016, 'Transfusion-related immunomodulation: Review of the literature and implications for pediatric critical illness', Transfusion. https://doi.org/10.1111/trf.13855
Muszynski, Jennifer A. ; Spinella, Philip C. ; Cholette, Jill M. ; Acker, Jason P. ; Hall, Mark W. ; Juffermans, Nicole P. ; Kelly, Daniel P. ; Blumberg, Neil ; Nicol, Kathleen ; Liedel, Jennifer L. ; Doctor, Allan ; Remy, Kenneth E. ; Tucci, Marisa ; Lacroix, Jacques ; Norris, Philip J. / Transfusion-related immunomodulation : Review of the literature and implications for pediatric critical illness. In: Transfusion. 2016.
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