Transforming growth factor-β signaling in normal and malignant hematopoiesis

Iris Isufi, Mahesh Seetharam, Li Zhou, Davendra Sohal, Joanna Opalinska, Perry Pahanish, Amit K. Verma

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is an important physiologic regulator of cell growth and differentiation. TGF-β has been shown to inhibit the proliferation of quiescent hematopoietic stem cells and stimulate the differentiation of late progenitors to erythroid and myeloid cells. Insensitivity to TGF-β is implicated in the pathogenesis of many myeloid and lymphoid neoplasms. Loss of extracellular TGF receptors and disruption of intracellular TGF-β signaling by oncogenes is seen in a variety of malignant and premalignant states. TGF-β can also affect tumor growth and survival by influencing the secretion of other growth factors and manipulation of the tumor microenvironment. Recent development of small molecule inhibitors of TGF-β receptors and other signaling intermediaries may allow us to modulate TGF signaling for future therapeutic interventions in cancer.

Original languageEnglish (US)
Pages (from-to)543-552
Number of pages10
JournalJournal of Interferon and Cytokine Research
Volume27
Issue number7
DOIs
StatePublished - Jul 2007

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Hematopoiesis
Transforming Growth Factors
Cell Differentiation
Myeloid Progenitor Cells
Neoplasms
Erythroid Precursor Cells
Tumor Microenvironment
Growth Factor Receptors
Growth
Hematopoietic Stem Cells
Oncogenes
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Cell Biology

Cite this

Transforming growth factor-β signaling in normal and malignant hematopoiesis. / Isufi, Iris; Seetharam, Mahesh; Zhou, Li; Sohal, Davendra; Opalinska, Joanna; Pahanish, Perry; Verma, Amit K.

In: Journal of Interferon and Cytokine Research, Vol. 27, No. 7, 07.2007, p. 543-552.

Research output: Contribution to journalArticle

Isufi, Iris ; Seetharam, Mahesh ; Zhou, Li ; Sohal, Davendra ; Opalinska, Joanna ; Pahanish, Perry ; Verma, Amit K. / Transforming growth factor-β signaling in normal and malignant hematopoiesis. In: Journal of Interferon and Cytokine Research. 2007 ; Vol. 27, No. 7. pp. 543-552.
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