Transforming growth factor-β signaling in normal and malignant hematopoiesis

Iris Isufi, Mahesh Seetharam, Li Zhou, Davendra Sohal, Joanna Opalinska, Perry Pahanish, Amit Verma

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) is an important physiologic regulator of cell growth and differentiation. TGF-β has been shown to inhibit the proliferation of quiescent hematopoietic stem cells and stimulate the differentiation of late progenitors to erythroid and myeloid cells. Insensitivity to TGF-β is implicated in the pathogenesis of many myeloid and lymphoid neoplasms. Loss of extracellular TGF receptors and disruption of intracellular TGF-β signaling by oncogenes is seen in a variety of malignant and premalignant states. TGF-β can also affect tumor growth and survival by influencing the secretion of other growth factors and manipulation of the tumor microenvironment. Recent development of small molecule inhibitors of TGF-β receptors and other signaling intermediaries may allow us to modulate TGF signaling for future therapeutic interventions in cancer.

Original languageEnglish (US)
Pages (from-to)543-552
Number of pages10
JournalJournal of Interferon and Cytokine Research
Volume27
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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