Transcripts of aging

Jan Vijg; R. Brent Calder

doi:10.1016/j.tig.2004.04.007

Transcripts of aging

Jan Vijg, R. Brent Calder

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	Trends in Genetics
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.tig.2004.04.007
State	Published - Jun 1 2004
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2004.04.007

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title = "Transcripts of aging",

abstract = "Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.",

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AU - Calder, R. Brent

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AB - Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.

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Transcripts of aging

Abstract

ASJC Scopus subject areas

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