Transcripts of aging

Jan Vijg, R. Brent Calder

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations


Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalTrends in Genetics
Issue number6
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Genetics


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