Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Satish K. Nandakumar, Christoph Muus, Jacob C. Ulirsch, Kaitavjeet Chowdhary, Jason D. Buenrostro, Narla Mohandas, Xiuli An, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Ludwig et al. chart the dynamic transcriptional and chromatin landscapes as hematopoietic stem and progenitor cells differentiate into mature red blood cells. This multi-omic profiling reveals dynamic transcription factor activities and human genetic variation that modulate this process.

Original languageEnglish (US)
Pages (from-to)3228-3240.e7
JournalCell Reports
Volume27
Issue number11
DOIs
StatePublished - Jun 11 2019
Externally publishedYes

Keywords

  • chromatin accessibility
  • erythropoiesis
  • GWAS
  • hematopoiesis
  • human genetics
  • red blood cell
  • transcriptomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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