@article{589f2e54a2014bfd854d582ce32286d7,
title = "Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis",
abstract = "Ludwig et al. chart the dynamic transcriptional and chromatin landscapes as hematopoietic stem and progenitor cells differentiate into mature red blood cells. This multi-omic profiling reveals dynamic transcription factor activities and human genetic variation that modulate this process.",
keywords = "GWAS, chromatin accessibility, erythropoiesis, hematopoiesis, human genetics, red blood cell, transcriptomics",
author = "Ludwig, {Leif S.} and Lareau, {Caleb A.} and Bao, {Erik L.} and Nandakumar, {Satish K.} and Christoph Muus and Ulirsch, {Jacob C.} and Kaitavjeet Chowdhary and Buenrostro, {Jason D.} and Narla Mohandas and Xiuli An and Aryee, {Martin J.} and Aviv Regev and Sankaran, {Vijay G.}",
note = "Funding Information: We thank members of the Sankaran, Regev, and Aryee laboratories for valuable comments and the Whitehead Institute and Broad Institute Flow Cytometry facilities for assistance with cell sorting and flow cytometric analysis. We thank Ryo Kurita and Yukio Nakamura for providing HUDEP-2 cells. E.L.B. received support from the Howard Hughes Medical Institute Medical Research Fellows program. K.C. received support from NIH training grant T32GM007753 . J.D.B. received support from the Broad Institute Fellows program and the Allen Institute Distinguished Investigator Award. This research was supported by NIH grant P01 DK32094 (N.M.), the Howard Hughes Medical Institute (A.R.), the Klarman Cell Observatory (A.R.), NIH grants R01 DK103794 and R33 HL120791 (V.G.S.), and the New York Stem Cell Foundation (NYSCF; V.G.S.). V.G.S. is a NYSCF-Robertson Investigator. Funding Information: We thank members of the Sankaran, Regev, and Aryee laboratories for valuable comments and the Whitehead Institute and Broad Institute Flow Cytometry facilities for assistance with cell sorting and flow cytometric analysis. We thank Ryo Kurita and Yukio Nakamura for providing HUDEP-2 cells. E.L.B. received support from the Howard Hughes Medical Institute Medical Research Fellows program. K.C. received support from NIH training grant T32GM007753. J.D.B. received support from the Broad Institute Fellows program and the Allen Institute Distinguished Investigator Award. This research was supported by NIH grant P01 DK32094 (N.M.), the Howard Hughes Medical Institute (A.R.), the Klarman Cell Observatory (A.R.), NIH grants R01 DK103794 and R33 HL120791 (V.G.S.), and the New York Stem Cell Foundation (NYSCF; V.G.S.). V.G.S. is a NYSCF-Robertson Investigator. Conceptualization, L.S.L. C.A.L. A.R. and V.G.S.; Methodology, L.S.L. C.A.L. E.L.B. J.C.U. S.N.K. A.R. and V.G.S.; Formal Analysis, C.A.L. E.L.B. J.C.U. and L.S.L. with input from M.J.A. J.D.B. A.R. and V.G.S.; Investigation, L.S.L. S.K.N. C.M. and K.C.; Resources, M.J.A. J.D.B. N.M. X.A. A.R. and V.G.S.; Writing – Original Draft, L.S.L. C.A.L. E.L.B. A.R. and V.G.S. with input from all authors; Writing – Review & Editing, L.S.L. C.A.L. E.L.B. A.R. and V.G.S. with input from all authors; Visualization, C.A.L. E.L.B. and L.S.L.; Supervision, N.M. X.A. M.J.A. A.R. and V.G.S.; Project Administration, A.R. and V.G.S.; Funding Acquisition, A.R. and V.G.S. A.R. is a founder and equity holder in Celsius Therapeutics and an SAB member of the ThermoFisher Scientific and Syros Pharmaceuticals. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = jun,
day = "11",
doi = "10.1016/j.celrep.2019.05.046",
language = "English (US)",
volume = "27",
pages = "3228--3240.e7",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}