TY - JOUR
T1 - Transcription cooperation by NFAT·C/EBP composite enhancer complex
AU - Yang, Teddy T.C.
AU - Chow, Chi Wing
PY - 2003/5/2
Y1 - 2003/5/2
N2 - The nuclear factor of activated T cells (NFAT) group of transcription factors regulates gene expression in immune and non-immune cells. NFAT-mediated gene transcription is orchestrated, in part, by formation of a composite regulatory element. Here we demonstrate that NFAT interacts with transcription factor CCAAT/enhancer-binding protein (C/EBP) to form a composite enhancer complex, to potentiate expression of the peroxisome proliferator-activated receptor-γ2 gene. Formation of a ternary NFAT·C/EBP·DNA complex is required for the transcriptional cooperation. A similar NFAT·C/EBP composite element is found in the regulatory region of the insulin-like growth factor 2, angiotensin-converting enzyme homolog, and transcription factor POU4F3 genes. Thus, the NFAT·C/EBP composite element represents a novel regulatory enhancer to direct NFAT-mediated gene transcription.
AB - The nuclear factor of activated T cells (NFAT) group of transcription factors regulates gene expression in immune and non-immune cells. NFAT-mediated gene transcription is orchestrated, in part, by formation of a composite regulatory element. Here we demonstrate that NFAT interacts with transcription factor CCAAT/enhancer-binding protein (C/EBP) to form a composite enhancer complex, to potentiate expression of the peroxisome proliferator-activated receptor-γ2 gene. Formation of a ternary NFAT·C/EBP·DNA complex is required for the transcriptional cooperation. A similar NFAT·C/EBP composite element is found in the regulatory region of the insulin-like growth factor 2, angiotensin-converting enzyme homolog, and transcription factor POU4F3 genes. Thus, the NFAT·C/EBP composite element represents a novel regulatory enhancer to direct NFAT-mediated gene transcription.
UR - http://www.scopus.com/inward/record.url?scp=0038182519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038182519&partnerID=8YFLogxK
U2 - 10.1074/jbc.M211560200
DO - 10.1074/jbc.M211560200
M3 - Article
C2 - 12606546
AN - SCOPUS:0038182519
SN - 0021-9258
VL - 278
SP - 15874
EP - 15885
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 18
ER -