Transcranial Magnetic Simulation in the Treatment of Migraine

Richard B. Lipton, Starr H. Pearlman

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Transcranial magnetic stimulation (TMS) is a diagnostic and therapeutic modality that is being developed as both an acute and preventive treatment for migraine. TMS delivers a fluctuating magnetic field from the scalp surface to induce current in the subjacent cortex. Magnetic pulses are delivered one at a time in single-pulse TMS (sTMS) or as a train of pulses in repetitive TMS (rTMS). For most of its 30-year history, TMS has been delivered in clinical and research settings using large tabletop devices. Based on the theory that sTMS may disrupt cortical spreading depression, sTMS has been studied and shown to be effective as an acute treatment for migraine with aura. Subsequent work in animal models confirms that sTMS disrupts cortical spreading depression. To make outpatient self-treatment possible, a portable device has been developed for acute treatment of migraine with aura. Based on the theory that rTMS alters brain excitability and neurotransmitter activity, rTMS has been studied as a preventive migraine treatment. A small body of evidence suggests that rTMS may have a role, but further studies are needed. In this review, we summarize the data on TMS as a treatment of migraine, and we suggest directions for future research.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalNeurotherapeutics
Volume7
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Migraine Disorders
Transcranial Magnetic Stimulation
Cortical Spreading Depression
Migraine with Aura
Therapeutics
Equipment and Supplies
Magnetic Fields
Scalp
Neurotransmitter Agents
Outpatients
Animal Models
History
Brain
Research

Keywords

  • acute treatment
  • cortical spreading depression
  • Migraine
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Cite this

Transcranial Magnetic Simulation in the Treatment of Migraine. / Lipton, Richard B.; Pearlman, Starr H.

In: Neurotherapeutics, Vol. 7, No. 2, 04.2010, p. 204-212.

Research output: Contribution to journalArticle

Lipton, Richard B. ; Pearlman, Starr H. / Transcranial Magnetic Simulation in the Treatment of Migraine. In: Neurotherapeutics. 2010 ; Vol. 7, No. 2. pp. 204-212.
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