Trajectories of function and biomarkers with age

the CHS All Stars Study

Anne B. Newman, Jason L. Sanders, Jorge Kizer, Robert M. Boudreau, Michelle C. Odden, Adina Zeki Al Hazzouri, Alice M. Arnold

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.

METHODS: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.

RESULTS: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.

CONCLUSIONS: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.

Original languageEnglish (US)
Pages (from-to)1135-1145
Number of pages11
JournalInternational Journal of Epidemiology
Volume45
Issue number4
StatePublished - Aug 1 2016

Fingerprint

Cystatin C
Hand Strength
Biomarkers
Health Status
Interleukin-6
Dehydroepiandrosterone Sulfate
Adiponectin
Health
Growth Hormone
Adiposity
Insulin-Like Growth Factor I
Comorbidity
Chronic Disease
Steroids
Insulin
Inflammation
Kidney
Walking Speed

Keywords

  • Ageing
  • biomarkers
  • cognitive function
  • disability
  • gait speed
  • grip strength

ASJC Scopus subject areas

  • Epidemiology

Cite this

Newman, A. B., Sanders, J. L., Kizer, J., Boudreau, R. M., Odden, M. C., Zeki Al Hazzouri, A., & Arnold, A. M. (2016). Trajectories of function and biomarkers with age: the CHS All Stars Study. International Journal of Epidemiology, 45(4), 1135-1145.

Trajectories of function and biomarkers with age : the CHS All Stars Study. / Newman, Anne B.; Sanders, Jason L.; Kizer, Jorge; Boudreau, Robert M.; Odden, Michelle C.; Zeki Al Hazzouri, Adina; Arnold, Alice M.

In: International Journal of Epidemiology, Vol. 45, No. 4, 01.08.2016, p. 1135-1145.

Research output: Contribution to journalArticle

Newman, AB, Sanders, JL, Kizer, J, Boudreau, RM, Odden, MC, Zeki Al Hazzouri, A & Arnold, AM 2016, 'Trajectories of function and biomarkers with age: the CHS All Stars Study', International Journal of Epidemiology, vol. 45, no. 4, pp. 1135-1145.
Newman AB, Sanders JL, Kizer J, Boudreau RM, Odden MC, Zeki Al Hazzouri A et al. Trajectories of function and biomarkers with age: the CHS All Stars Study. International Journal of Epidemiology. 2016 Aug 1;45(4):1135-1145.
Newman, Anne B. ; Sanders, Jason L. ; Kizer, Jorge ; Boudreau, Robert M. ; Odden, Michelle C. ; Zeki Al Hazzouri, Adina ; Arnold, Alice M. / Trajectories of function and biomarkers with age : the CHS All Stars Study. In: International Journal of Epidemiology. 2016 ; Vol. 45, No. 4. pp. 1135-1145.
@article{3d94e5d3a5a34bbc8a51972e22d77ec7,
title = "Trajectories of function and biomarkers with age: the CHS All Stars Study",
abstract = "BACKGROUND: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.METHODS: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.RESULTS: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.CONCLUSIONS: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.",
keywords = "Ageing, biomarkers, cognitive function, disability, gait speed, grip strength",
author = "Newman, {Anne B.} and Sanders, {Jason L.} and Jorge Kizer and Boudreau, {Robert M.} and Odden, {Michelle C.} and {Zeki Al Hazzouri}, Adina and Arnold, {Alice M.}",
year = "2016",
month = "8",
day = "1",
language = "English (US)",
volume = "45",
pages = "1135--1145",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Trajectories of function and biomarkers with age

T2 - the CHS All Stars Study

AU - Newman, Anne B.

AU - Sanders, Jason L.

AU - Kizer, Jorge

AU - Boudreau, Robert M.

AU - Odden, Michelle C.

AU - Zeki Al Hazzouri, Adina

AU - Arnold, Alice M.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - BACKGROUND: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.METHODS: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.RESULTS: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.CONCLUSIONS: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.

AB - BACKGROUND: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.METHODS: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.RESULTS: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.CONCLUSIONS: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.

KW - Ageing

KW - biomarkers

KW - cognitive function

KW - disability

KW - gait speed

KW - grip strength

UR - http://www.scopus.com/inward/record.url?scp=85014417215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014417215&partnerID=8YFLogxK

M3 - Article

VL - 45

SP - 1135

EP - 1145

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 4

ER -