Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause

Samar R. El Khoudary, Nanette Santoro, Hsiang Yu Chen, Ping G. Tepper, Maria M. Brooks, Rebecca C. Thurston, Imke Janssen, Sioban D. Harlow, Emma Barinas-Mitchell, Faith Selzer, Carol A. Derby, Elizabeth A. Jackson, Daniel McConnell, Karen A. Matthews

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aim The purpose of this study was to assess associations between distinct patterns of circulating estradiol (E2) and follicle-stimulating hormone (FSH) over the menopause transition (MT) and subclinical measures of atherosclerosis after menopause. Methods and results Four temporal patterns of E2 decline (Low: low before and after final menstrual period (FMP); Medium: medium before and high after FMP; High-early decline: high prior to FMP and early decline thereafter; High-late decline: high prior to FMP and late decline thereafter) and three of FSH rise (Low, Medium, High) over 9.6 years across FMP were identified and linked to carotid intima-media-thickness (IMT), adventitial diameter (AD), and presence of carotid plaque (cPlaque) measured after menopause at the 12th annual visit (visit 12). Participants were 856 women (age at visit 12 = 59.5 ± 2.7 years) from the Study of Women's Health Across the Nation (SWAN), who never reported a stroke or a heart attack. In models adjusted for visit 12 or baseline cardiovascular disease (CVD) risk factors, odds of having any cPlaque were ∼43% lower among women with the High-early decline E2 trajectory compared to women with the Low E2 trajectory. In contrast, women with the Medium E2 trajectory had significantly higher IMT than those with the Low E2 trajectory adjusting for visit 12 CVD risk factors. Interestingly, adjusting for baseline CVD risk factors attenuated this association. The Low FSH group had lower IMT than the Medium and High FSH groups (p ≤ 0.05) in all models. Conclusion During MT, women are subjected to hormonal alterations that could potentially increase their risk of developing CVD after menopause.

Original languageEnglish (US)
Pages (from-to)694-703
Number of pages10
JournalEuropean Journal of Preventive Cardiology
Volume23
Issue number7
DOIs
StatePublished - 2015

Fingerprint

Follicle Stimulating Hormone
Menopause
Estradiol
Atherosclerosis
Cardiovascular Diseases
Adventitia
Carotid Intima-Media Thickness
Women's Health
Stroke
Myocardial Infarction

Keywords

  • atherosclerosis
  • epidemiology
  • Estradiol
  • intima-media thickness
  • menopause
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

Cite this

Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause. / El Khoudary, Samar R.; Santoro, Nanette; Chen, Hsiang Yu; Tepper, Ping G.; Brooks, Maria M.; Thurston, Rebecca C.; Janssen, Imke; Harlow, Sioban D.; Barinas-Mitchell, Emma; Selzer, Faith; Derby, Carol A.; Jackson, Elizabeth A.; McConnell, Daniel; Matthews, Karen A.

In: European Journal of Preventive Cardiology, Vol. 23, No. 7, 2015, p. 694-703.

Research output: Contribution to journalArticle

El Khoudary, SR, Santoro, N, Chen, HY, Tepper, PG, Brooks, MM, Thurston, RC, Janssen, I, Harlow, SD, Barinas-Mitchell, E, Selzer, F, Derby, CA, Jackson, EA, McConnell, D & Matthews, KA 2015, 'Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause', European Journal of Preventive Cardiology, vol. 23, no. 7, pp. 694-703. https://doi.org/10.1177/2047487315607044
El Khoudary, Samar R. ; Santoro, Nanette ; Chen, Hsiang Yu ; Tepper, Ping G. ; Brooks, Maria M. ; Thurston, Rebecca C. ; Janssen, Imke ; Harlow, Sioban D. ; Barinas-Mitchell, Emma ; Selzer, Faith ; Derby, Carol A. ; Jackson, Elizabeth A. ; McConnell, Daniel ; Matthews, Karen A. / Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause. In: European Journal of Preventive Cardiology. 2015 ; Vol. 23, No. 7. pp. 694-703.
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abstract = "Aim The purpose of this study was to assess associations between distinct patterns of circulating estradiol (E2) and follicle-stimulating hormone (FSH) over the menopause transition (MT) and subclinical measures of atherosclerosis after menopause. Methods and results Four temporal patterns of E2 decline (Low: low before and after final menstrual period (FMP); Medium: medium before and high after FMP; High-early decline: high prior to FMP and early decline thereafter; High-late decline: high prior to FMP and late decline thereafter) and three of FSH rise (Low, Medium, High) over 9.6 years across FMP were identified and linked to carotid intima-media-thickness (IMT), adventitial diameter (AD), and presence of carotid plaque (cPlaque) measured after menopause at the 12th annual visit (visit 12). Participants were 856 women (age at visit 12 = 59.5 ± 2.7 years) from the Study of Women's Health Across the Nation (SWAN), who never reported a stroke or a heart attack. In models adjusted for visit 12 or baseline cardiovascular disease (CVD) risk factors, odds of having any cPlaque were ∼43{\%} lower among women with the High-early decline E2 trajectory compared to women with the Low E2 trajectory. In contrast, women with the Medium E2 trajectory had significantly higher IMT than those with the Low E2 trajectory adjusting for visit 12 CVD risk factors. Interestingly, adjusting for baseline CVD risk factors attenuated this association. The Low FSH group had lower IMT than the Medium and High FSH groups (p ≤ 0.05) in all models. Conclusion During MT, women are subjected to hormonal alterations that could potentially increase their risk of developing CVD after menopause.",
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T1 - Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause

AU - El Khoudary, Samar R.

AU - Santoro, Nanette

AU - Chen, Hsiang Yu

AU - Tepper, Ping G.

AU - Brooks, Maria M.

AU - Thurston, Rebecca C.

AU - Janssen, Imke

AU - Harlow, Sioban D.

AU - Barinas-Mitchell, Emma

AU - Selzer, Faith

AU - Derby, Carol A.

AU - Jackson, Elizabeth A.

AU - McConnell, Daniel

AU - Matthews, Karen A.

PY - 2015

Y1 - 2015

N2 - Aim The purpose of this study was to assess associations between distinct patterns of circulating estradiol (E2) and follicle-stimulating hormone (FSH) over the menopause transition (MT) and subclinical measures of atherosclerosis after menopause. Methods and results Four temporal patterns of E2 decline (Low: low before and after final menstrual period (FMP); Medium: medium before and high after FMP; High-early decline: high prior to FMP and early decline thereafter; High-late decline: high prior to FMP and late decline thereafter) and three of FSH rise (Low, Medium, High) over 9.6 years across FMP were identified and linked to carotid intima-media-thickness (IMT), adventitial diameter (AD), and presence of carotid plaque (cPlaque) measured after menopause at the 12th annual visit (visit 12). Participants were 856 women (age at visit 12 = 59.5 ± 2.7 years) from the Study of Women's Health Across the Nation (SWAN), who never reported a stroke or a heart attack. In models adjusted for visit 12 or baseline cardiovascular disease (CVD) risk factors, odds of having any cPlaque were ∼43% lower among women with the High-early decline E2 trajectory compared to women with the Low E2 trajectory. In contrast, women with the Medium E2 trajectory had significantly higher IMT than those with the Low E2 trajectory adjusting for visit 12 CVD risk factors. Interestingly, adjusting for baseline CVD risk factors attenuated this association. The Low FSH group had lower IMT than the Medium and High FSH groups (p ≤ 0.05) in all models. Conclusion During MT, women are subjected to hormonal alterations that could potentially increase their risk of developing CVD after menopause.

AB - Aim The purpose of this study was to assess associations between distinct patterns of circulating estradiol (E2) and follicle-stimulating hormone (FSH) over the menopause transition (MT) and subclinical measures of atherosclerosis after menopause. Methods and results Four temporal patterns of E2 decline (Low: low before and after final menstrual period (FMP); Medium: medium before and high after FMP; High-early decline: high prior to FMP and early decline thereafter; High-late decline: high prior to FMP and late decline thereafter) and three of FSH rise (Low, Medium, High) over 9.6 years across FMP were identified and linked to carotid intima-media-thickness (IMT), adventitial diameter (AD), and presence of carotid plaque (cPlaque) measured after menopause at the 12th annual visit (visit 12). Participants were 856 women (age at visit 12 = 59.5 ± 2.7 years) from the Study of Women's Health Across the Nation (SWAN), who never reported a stroke or a heart attack. In models adjusted for visit 12 or baseline cardiovascular disease (CVD) risk factors, odds of having any cPlaque were ∼43% lower among women with the High-early decline E2 trajectory compared to women with the Low E2 trajectory. In contrast, women with the Medium E2 trajectory had significantly higher IMT than those with the Low E2 trajectory adjusting for visit 12 CVD risk factors. Interestingly, adjusting for baseline CVD risk factors attenuated this association. The Low FSH group had lower IMT than the Medium and High FSH groups (p ≤ 0.05) in all models. Conclusion During MT, women are subjected to hormonal alterations that could potentially increase their risk of developing CVD after menopause.

KW - atherosclerosis

KW - epidemiology

KW - Estradiol

KW - intima-media thickness

KW - menopause

KW - women

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