Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser

Joseph S. Auteri, Valluvan Jeevanandam, Mehmet C. Oz, Steven K. Libutti, Thomas J. Kirby, Craig R. Smith, Michael R. Treat

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

A major obstacle to lung transplantation and combined heart-lung transplantation is dehiscence of the tracheobronchial anastomosis. We explored the possibility of laser welded anastomoses in canine tracheas in vivo. Laser anastomoses were performed on three-quarter circumferential anterior tracheotomies. A continuous wave diode laser (808 ±1 nm) at a power density of 9.6 watts/cm2 was used. Human fibrinogen was mixed with indocyanine green dye (ICG, max absorbance 805 nm) and applied to the anastomosis site prior to laser exposure. Animals were sacrificed at 0, 21 and 28 days post-operatively. At sacrifice weld bursting pressures were measured by raising intratracheal pressure using forced ventilation via an endotracheal tube. Sutured and laser welded anastomoses had similar bursting pressures, and exhibited satisfactory histologic evidence of healing. However, compared to polypropylene sutured controls, the laser welded anastomoses exhibited less peritracheal inflammatory reaction and showed visibly smoother luminal surfaces at 21 and 28 days post-operatively. Tracheal anastomosis using ICG dye enhanced fibrinogen combined with the near-infrared diode laser is a promising extension of the technology of laser tissue fusion and deserves further study.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsStephen N. Joffe, Kazuhiko Atsumi
PublisherPubl by Int Soc for Optical Engineering
Pages60-63
Number of pages4
Volume1200
ISBN (Print)0819402419
StatePublished - 1990
Externally publishedYes
EventProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II - Los Angeles, CA, USA
Duration: Jan 14 1990Jan 19 1990

Other

OtherProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II
CityLos Angeles, CA, USA
Period1/14/901/19/90

Fingerprint

fibrinogen
Semiconductor lasers
Dyes
dyes
semiconductor lasers
Infrared radiation
Lasers
lasers
transplantation
lungs
trachea
ventilation
healing
polypropylene
Ventilation
continuous radiation
animals
radiant flux density
Polypropylenes
Welds

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Auteri, J. S., Jeevanandam, V., Oz, M. C., Libutti, S. K., Kirby, T. J., Smith, C. R., & Treat, M. R. (1990). Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser. In S. N. Joffe, & K. Atsumi (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1200, pp. 60-63). Publ by Int Soc for Optical Engineering.

Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser. / Auteri, Joseph S.; Jeevanandam, Valluvan; Oz, Mehmet C.; Libutti, Steven K.; Kirby, Thomas J.; Smith, Craig R.; Treat, Michael R.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Stephen N. Joffe; Kazuhiko Atsumi. Vol. 1200 Publ by Int Soc for Optical Engineering, 1990. p. 60-63.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Auteri, JS, Jeevanandam, V, Oz, MC, Libutti, SK, Kirby, TJ, Smith, CR & Treat, MR 1990, Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser. in SN Joffe & K Atsumi (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1200, Publ by Int Soc for Optical Engineering, pp. 60-63, Proceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II, Los Angeles, CA, USA, 1/14/90.
Auteri JS, Jeevanandam V, Oz MC, Libutti SK, Kirby TJ, Smith CR et al. Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser. In Joffe SN, Atsumi K, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1200. Publ by Int Soc for Optical Engineering. 1990. p. 60-63
Auteri, Joseph S. ; Jeevanandam, Valluvan ; Oz, Mehmet C. ; Libutti, Steven K. ; Kirby, Thomas J. ; Smith, Craig R. ; Treat, Michael R. / Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser. Proceedings of SPIE - The International Society for Optical Engineering. editor / Stephen N. Joffe ; Kazuhiko Atsumi. Vol. 1200 Publ by Int Soc for Optical Engineering, 1990. pp. 60-63
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