Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Mathieu Gissot, Sang Woon Choi, Reid F. Thompson, John M. Greally, Kami Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalEukaryotic Cell
Volume7
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Cryptosporidium parvum
cytosine
Cytosine
Toxoplasma
DNA Methylation
Toxoplasma gondii
methylation
Apicomplexa
DNA
Epigenomics
Methylation
Virulence
Mass Spectrometry
Genome
epigenetics
virulence
Enzymes
mass spectrometry
genome
organisms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Microbiology

Cite this

Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. / Gissot, Mathieu; Choi, Sang Woon; Thompson, Reid F.; Greally, John M.; Kim, Kami.

In: Eukaryotic Cell, Vol. 7, No. 3, 03.2008, p. 537-540.

Research output: Contribution to journalArticle

Gissot, Mathieu ; Choi, Sang Woon ; Thompson, Reid F. ; Greally, John M. ; Kim, Kami. / Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. In: Eukaryotic Cell. 2008 ; Vol. 7, No. 3. pp. 537-540.
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