Toward a systems biology framework for understanding aging and health span

Geoffrey B. West, Aviv Bergman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number2
DOIs
StatePublished - Feb 2009

Fingerprint

Systems Biology
Health
Research

Keywords

  • Aging
  • Biology
  • Health span

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Toward a systems biology framework for understanding aging and health span. / West, Geoffrey B.; Bergman, Aviv.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 2, 02.2009, p. 205-208.

Research output: Contribution to journalArticle

@article{71ceeb370db340dbbb506999ada645eb,
title = "Toward a systems biology framework for understanding aging and health span",
abstract = "It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.",
keywords = "Aging, Biology, Health span",
author = "West, {Geoffrey B.} and Aviv Bergman",
year = "2009",
month = "2",
doi = "10.1093/gerona/gln066",
language = "English (US)",
volume = "64",
pages = "205--208",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Toward a systems biology framework for understanding aging and health span

AU - West, Geoffrey B.

AU - Bergman, Aviv

PY - 2009/2

Y1 - 2009/2

N2 - It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.

AB - It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.

KW - Aging

KW - Biology

KW - Health span

UR - http://www.scopus.com/inward/record.url?scp=64949135371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64949135371&partnerID=8YFLogxK

U2 - 10.1093/gerona/gln066

DO - 10.1093/gerona/gln066

M3 - Article

C2 - 19223604

AN - SCOPUS:64949135371

VL - 64

SP - 205

EP - 208

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 2

ER -