Toward a positive aging phenotype for older women

Observations from the women's health initiative

Nancy Fugate Woods, Barbara B. Cochrane, Andrea Z. Lacroix, Rebecca A. Seguin, Oleg Zaslavsky, Jingmin Liu, Jeannette M. Beasley, Robert L. Brunner, Mark A. Espeland, Joseph S. Goveas, Dorothy S. Lane, Joann E. Manson, Charles P. Mouton, Jennifer G. Robinson, Lesley F. Tinker

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: To develop a positive aging phenotype, we undertook analyses to describe multiple dimensions of positive aging and their relationships to one another in women 65 years of age and older and evaluate the performance of individual indicators and composite factors of this phenotype as predictors of time to death, years of healthy living, and years of independent living. Methods: Data from Women's Health Initiative clinical trial and observational study participants ages 65 years and older at baseline, including follow-up observations up to 8 years later, were analyzed using descriptive statistics and principal components analysis to identify the factor structure of a positive aging phenotype. The factors were used to predict time to death, years of healthy living (without hospitalization or diagnosis of a serious health condition), and years of independent living (without nursing home admission or use of special services). Results: We identified a multidimensional phenotype of positive aging that included two factors: Physical-Social Functioning and Emotional Functioning. Both factors were predictive of each of the outcomes, but Physical-Social Functioning was the strongest predictor. Each standard deviation of increase in Physical-Social Functioning was accompanied by a 23.7% reduction in mortality risk, a 19.4% reduction in risk of major health conditions or hospitalizations, and a 26.3% reduction in risk of dependent living. Conclusions: Physical-Social Functioning and Emotional Functioning constitute important components of a positive aging phenotype. Physical-Social Functioning was the strongest predictor of outcomes related to positive aging, including years of healthy living, years of independent living, and time to mortality.

Original languageEnglish (US)
Pages (from-to)1191-1196
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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Women's Health
Independent Living
Phenotype
Risk Reduction Behavior
Hospitalization
Mortality
Health
Nursing Homes
Principal Component Analysis
Observational Studies
Clinical Trials

Keywords

  • Healthy life span
  • Phenotypes
  • Positive aging
  • Women's health

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Toward a positive aging phenotype for older women : Observations from the women's health initiative. / Woods, Nancy Fugate; Cochrane, Barbara B.; Lacroix, Andrea Z.; Seguin, Rebecca A.; Zaslavsky, Oleg; Liu, Jingmin; Beasley, Jeannette M.; Brunner, Robert L.; Espeland, Mark A.; Goveas, Joseph S.; Lane, Dorothy S.; Manson, Joann E.; Mouton, Charles P.; Robinson, Jennifer G.; Tinker, Lesley F.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 67, No. 11, 11.2012, p. 1191-1196.

Research output: Contribution to journalArticle

Woods, NF, Cochrane, BB, Lacroix, AZ, Seguin, RA, Zaslavsky, O, Liu, J, Beasley, JM, Brunner, RL, Espeland, MA, Goveas, JS, Lane, DS, Manson, JE, Mouton, CP, Robinson, JG & Tinker, LF 2012, 'Toward a positive aging phenotype for older women: Observations from the women's health initiative', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 67, no. 11, pp. 1191-1196. https://doi.org/10.1093/gerona/gls117
Woods, Nancy Fugate ; Cochrane, Barbara B. ; Lacroix, Andrea Z. ; Seguin, Rebecca A. ; Zaslavsky, Oleg ; Liu, Jingmin ; Beasley, Jeannette M. ; Brunner, Robert L. ; Espeland, Mark A. ; Goveas, Joseph S. ; Lane, Dorothy S. ; Manson, Joann E. ; Mouton, Charles P. ; Robinson, Jennifer G. ; Tinker, Lesley F. / Toward a positive aging phenotype for older women : Observations from the women's health initiative. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2012 ; Vol. 67, No. 11. pp. 1191-1196.
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AU - Lacroix, Andrea Z.

AU - Seguin, Rebecca A.

AU - Zaslavsky, Oleg

AU - Liu, Jingmin

AU - Beasley, Jeannette M.

AU - Brunner, Robert L.

AU - Espeland, Mark A.

AU - Goveas, Joseph S.

AU - Lane, Dorothy S.

AU - Manson, Joann E.

AU - Mouton, Charles P.

AU - Robinson, Jennifer G.

AU - Tinker, Lesley F.

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