Total parenteral nutrition associated with severe insulin resistance following hematopoietic stem cell transplantation in patients with hemophagocytic syndrome: Report on two cases

Deepa Suresh, Ioanna Athanassaki, George S. Jeha, Rubina A. Heptulla

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Suresh D, Athanassaki I, Jeha GS, Heptulla RA. Total parenteral nutrition associated with severe insulin resistance following hematopoietic stem cell transplantation in patients with hemophagocytic syndrome: report on two cases.Hyperglycemia secondary to total parenteral nutrition (TPN) is reported in adults. In addition, insulin resistance and type 2 diabetes as late consequences of hematopoietic stem cell transplantation (HSCT) are well described. Both situations are generally manageable with traditional insulin dosing. We present two children who developed severe insulin resistance requiring intravenous insulin therapy at doses up to 13 units/kg/h. Both children were on TPN after undergoing HSCT for hemophagocytic syndrome. We believe that our report will alert physicians to such a condition and help with early recognition that is a key to successful intervention. These cases aim to increase awareness and stimulate research to unravel the associated underling mechanisms.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalPediatric Diabetes
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2010

Keywords

  • BMT-high-dose insulin
  • HLH
  • Hyperglycemia
  • Pediatrics

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

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