Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults

Robert C. Kaplan, Aileen P. McGinn, Michael N. Pollak, Lewis Kuller, Howard Strickler, Thomas E. Rohan, Xiaonan (Nan) Xue, Stephen B. Kritchevsky, Anne B. Newman, Bruce M. Psaty

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVES: To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults. DESIGN: Cohort study. SETTING/PARTICIPANTS: One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study. MEASUREMENTS: Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality. RESULTS: Higher IGFBP-1 predicted worse handgrip strength (P-trendT1-T3<. 01) and slower walking speed (P-trendT1-T3=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend T1-T3=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend T1-T3<.001, hazard ratio (HR)T3vsT1=1.48, 95% confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trendT1-T3=.05, HR T3vsT1=1.35, 95% CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trendT1-T3=.04, HRT3vsT1=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties. CONCLUSION: In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.

Original languageEnglish (US)
Pages (from-to)652-660
Number of pages9
JournalJournal of the American Geriatrics Society
Volume56
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Intercellular Signaling Peptides and Proteins
Carrier Proteins
Mortality
Activities of Daily Living
Confidence Intervals
Social Adjustment
Aptitude
Hand Strength
Fasting
Cohort Studies
Cardiovascular Diseases
Health

Keywords

  • Disability
  • Insulinlike growth factor (IGF)
  • Older adults

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults. / Kaplan, Robert C.; McGinn, Aileen P.; Pollak, Michael N.; Kuller, Lewis; Strickler, Howard; Rohan, Thomas E.; Xue, Xiaonan (Nan); Kritchevsky, Stephen B.; Newman, Anne B.; Psaty, Bruce M.

In: Journal of the American Geriatrics Society, Vol. 56, No. 4, 04.2008, p. 652-660.

Research output: Contribution to journalArticle

@article{2a72bbda4d394fdf97f8e23ff25dcb1b,
title = "Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults",
abstract = "OBJECTIVES: To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults. DESIGN: Cohort study. SETTING/PARTICIPANTS: One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study. MEASUREMENTS: Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality. RESULTS: Higher IGFBP-1 predicted worse handgrip strength (P-trendT1-T3<. 01) and slower walking speed (P-trendT1-T3=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend T1-T3=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend T1-T3<.001, hazard ratio (HR)T3vsT1=1.48, 95{\%} confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trendT1-T3=.05, HR T3vsT1=1.35, 95{\%} CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trendT1-T3=.04, HRT3vsT1=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties. CONCLUSION: In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.",
keywords = "Disability, Insulinlike growth factor (IGF), Older adults",
author = "Kaplan, {Robert C.} and McGinn, {Aileen P.} and Pollak, {Michael N.} and Lewis Kuller and Howard Strickler and Rohan, {Thomas E.} and Xue, {Xiaonan (Nan)} and Kritchevsky, {Stephen B.} and Newman, {Anne B.} and Psaty, {Bruce M.}",
year = "2008",
month = "4",
doi = "10.1111/j.1532-5415.2007.01637.x",
language = "English (US)",
volume = "56",
pages = "652--660",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults

AU - Kaplan, Robert C.

AU - McGinn, Aileen P.

AU - Pollak, Michael N.

AU - Kuller, Lewis

AU - Strickler, Howard

AU - Rohan, Thomas E.

AU - Xue, Xiaonan (Nan)

AU - Kritchevsky, Stephen B.

AU - Newman, Anne B.

AU - Psaty, Bruce M.

PY - 2008/4

Y1 - 2008/4

N2 - OBJECTIVES: To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults. DESIGN: Cohort study. SETTING/PARTICIPANTS: One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study. MEASUREMENTS: Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality. RESULTS: Higher IGFBP-1 predicted worse handgrip strength (P-trendT1-T3<. 01) and slower walking speed (P-trendT1-T3=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend T1-T3=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend T1-T3<.001, hazard ratio (HR)T3vsT1=1.48, 95% confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trendT1-T3=.05, HR T3vsT1=1.35, 95% CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trendT1-T3=.04, HRT3vsT1=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties. CONCLUSION: In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.

AB - OBJECTIVES: To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults. DESIGN: Cohort study. SETTING/PARTICIPANTS: One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study. MEASUREMENTS: Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality. RESULTS: Higher IGFBP-1 predicted worse handgrip strength (P-trendT1-T3<. 01) and slower walking speed (P-trendT1-T3=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend T1-T3=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend T1-T3<.001, hazard ratio (HR)T3vsT1=1.48, 95% confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trendT1-T3=.05, HR T3vsT1=1.35, 95% CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trendT1-T3=.04, HRT3vsT1=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties. CONCLUSION: In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.

KW - Disability

KW - Insulinlike growth factor (IGF)

KW - Older adults

UR - http://www.scopus.com/inward/record.url?scp=41549163949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41549163949&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2007.01637.x

DO - 10.1111/j.1532-5415.2007.01637.x

M3 - Article

VL - 56

SP - 652

EP - 660

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 4

ER -