Total and high-molecular-weight adiponectin and risk of incident diabetes in older people

Jorge Kizer, Joshua I. Barzilay, Alice M. Arnold, Russell P. Tracy, David Benkeser, Christos S. Mantzoros, Joachim H. Ix, David S. Siscovick, Luc Djousse, Kenneth J. Mukamal, Susan J. Zieman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

OBJECTIVE - To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS - Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were assessed in 3,802 individuals. RESULTS - Total and HMW adiponectin were highly correlated (r = 0.94). Analysis using cubic splines revealed that the associations between total and HMWadiponectin and new-onset diabeteswere not linear. Specifically, after adjustment for confounders, there were similar inverse relationships for total (hazard ratio per SD 0.49 [95% CI 0.39-0.63]) and HMW adiponectin (0.42 [0.32-0.56]) with diabetes up to values of 20 and 10 mg/L, respectively, above which the associations plateaued. These associations persisted after adjustment for potential mediators (blood pressure, lipids, C-reactive protein, and homeostasis model assessment of insulin resistance [HOMA-IR]). There was, however, evidence of interaction by HOMA-IR in the lower range of adiponectin, with stronger inverse associations among insulin-sensitive than insulin-resistant participants. HMW-to-total adiponectin ratio showed a linear adjusted association with outcome, but this was abolished by inclusion of mediating variables. CONCLUSIONS - In this older cohort, increasing concentrations of total and HMW adiponectin were associated with comparably lower risks of diabetes, but these associations leveled off with further increases above concentrations of 20 and 10 mg/L, respectively. The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.

Original languageEnglish (US)
Pages (from-to)415-423
Number of pages9
JournalDiabetes Care
Volume35
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Adiponectin
Molecular Weight
Insulin Resistance
Homeostasis
Insulin
Hyperinsulinism
C-Reactive Protein
Research Design
Blood Pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Kizer, J., Barzilay, J. I., Arnold, A. M., Tracy, R. P., Benkeser, D., Mantzoros, C. S., ... Zieman, S. J. (2012). Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. Diabetes Care, 35(2), 415-423. https://doi.org/10.2337/dc11-1519

Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. / Kizer, Jorge; Barzilay, Joshua I.; Arnold, Alice M.; Tracy, Russell P.; Benkeser, David; Mantzoros, Christos S.; Ix, Joachim H.; Siscovick, David S.; Djousse, Luc; Mukamal, Kenneth J.; Zieman, Susan J.

In: Diabetes Care, Vol. 35, No. 2, 02.2012, p. 415-423.

Research output: Contribution to journalArticle

Kizer, J, Barzilay, JI, Arnold, AM, Tracy, RP, Benkeser, D, Mantzoros, CS, Ix, JH, Siscovick, DS, Djousse, L, Mukamal, KJ & Zieman, SJ 2012, 'Total and high-molecular-weight adiponectin and risk of incident diabetes in older people', Diabetes Care, vol. 35, no. 2, pp. 415-423. https://doi.org/10.2337/dc11-1519
Kizer J, Barzilay JI, Arnold AM, Tracy RP, Benkeser D, Mantzoros CS et al. Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. Diabetes Care. 2012 Feb;35(2):415-423. https://doi.org/10.2337/dc11-1519
Kizer, Jorge ; Barzilay, Joshua I. ; Arnold, Alice M. ; Tracy, Russell P. ; Benkeser, David ; Mantzoros, Christos S. ; Ix, Joachim H. ; Siscovick, David S. ; Djousse, Luc ; Mukamal, Kenneth J. ; Zieman, Susan J. / Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. In: Diabetes Care. 2012 ; Vol. 35, No. 2. pp. 415-423.
@article{0c887aea01754902a424a46fc0117b31,
title = "Total and high-molecular-weight adiponectin and risk of incident diabetes in older people",
abstract = "OBJECTIVE - To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS - Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were assessed in 3,802 individuals. RESULTS - Total and HMW adiponectin were highly correlated (r = 0.94). Analysis using cubic splines revealed that the associations between total and HMWadiponectin and new-onset diabeteswere not linear. Specifically, after adjustment for confounders, there were similar inverse relationships for total (hazard ratio per SD 0.49 [95{\%} CI 0.39-0.63]) and HMW adiponectin (0.42 [0.32-0.56]) with diabetes up to values of 20 and 10 mg/L, respectively, above which the associations plateaued. These associations persisted after adjustment for potential mediators (blood pressure, lipids, C-reactive protein, and homeostasis model assessment of insulin resistance [HOMA-IR]). There was, however, evidence of interaction by HOMA-IR in the lower range of adiponectin, with stronger inverse associations among insulin-sensitive than insulin-resistant participants. HMW-to-total adiponectin ratio showed a linear adjusted association with outcome, but this was abolished by inclusion of mediating variables. CONCLUSIONS - In this older cohort, increasing concentrations of total and HMW adiponectin were associated with comparably lower risks of diabetes, but these associations leveled off with further increases above concentrations of 20 and 10 mg/L, respectively. The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.",
author = "Jorge Kizer and Barzilay, {Joshua I.} and Arnold, {Alice M.} and Tracy, {Russell P.} and David Benkeser and Mantzoros, {Christos S.} and Ix, {Joachim H.} and Siscovick, {David S.} and Luc Djousse and Mukamal, {Kenneth J.} and Zieman, {Susan J.}",
year = "2012",
month = "2",
doi = "10.2337/dc11-1519",
language = "English (US)",
volume = "35",
pages = "415--423",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "2",

}

TY - JOUR

T1 - Total and high-molecular-weight adiponectin and risk of incident diabetes in older people

AU - Kizer, Jorge

AU - Barzilay, Joshua I.

AU - Arnold, Alice M.

AU - Tracy, Russell P.

AU - Benkeser, David

AU - Mantzoros, Christos S.

AU - Ix, Joachim H.

AU - Siscovick, David S.

AU - Djousse, Luc

AU - Mukamal, Kenneth J.

AU - Zieman, Susan J.

PY - 2012/2

Y1 - 2012/2

N2 - OBJECTIVE - To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS - Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were assessed in 3,802 individuals. RESULTS - Total and HMW adiponectin were highly correlated (r = 0.94). Analysis using cubic splines revealed that the associations between total and HMWadiponectin and new-onset diabeteswere not linear. Specifically, after adjustment for confounders, there were similar inverse relationships for total (hazard ratio per SD 0.49 [95% CI 0.39-0.63]) and HMW adiponectin (0.42 [0.32-0.56]) with diabetes up to values of 20 and 10 mg/L, respectively, above which the associations plateaued. These associations persisted after adjustment for potential mediators (blood pressure, lipids, C-reactive protein, and homeostasis model assessment of insulin resistance [HOMA-IR]). There was, however, evidence of interaction by HOMA-IR in the lower range of adiponectin, with stronger inverse associations among insulin-sensitive than insulin-resistant participants. HMW-to-total adiponectin ratio showed a linear adjusted association with outcome, but this was abolished by inclusion of mediating variables. CONCLUSIONS - In this older cohort, increasing concentrations of total and HMW adiponectin were associated with comparably lower risks of diabetes, but these associations leveled off with further increases above concentrations of 20 and 10 mg/L, respectively. The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.

AB - OBJECTIVE - To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS - Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were assessed in 3,802 individuals. RESULTS - Total and HMW adiponectin were highly correlated (r = 0.94). Analysis using cubic splines revealed that the associations between total and HMWadiponectin and new-onset diabeteswere not linear. Specifically, after adjustment for confounders, there were similar inverse relationships for total (hazard ratio per SD 0.49 [95% CI 0.39-0.63]) and HMW adiponectin (0.42 [0.32-0.56]) with diabetes up to values of 20 and 10 mg/L, respectively, above which the associations plateaued. These associations persisted after adjustment for potential mediators (blood pressure, lipids, C-reactive protein, and homeostasis model assessment of insulin resistance [HOMA-IR]). There was, however, evidence of interaction by HOMA-IR in the lower range of adiponectin, with stronger inverse associations among insulin-sensitive than insulin-resistant participants. HMW-to-total adiponectin ratio showed a linear adjusted association with outcome, but this was abolished by inclusion of mediating variables. CONCLUSIONS - In this older cohort, increasing concentrations of total and HMW adiponectin were associated with comparably lower risks of diabetes, but these associations leveled off with further increases above concentrations of 20 and 10 mg/L, respectively. The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.

UR - http://www.scopus.com/inward/record.url?scp=84859062772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859062772&partnerID=8YFLogxK

U2 - 10.2337/dc11-1519

DO - 10.2337/dc11-1519

M3 - Article

C2 - 22148099

AN - SCOPUS:84859062772

VL - 35

SP - 415

EP - 423

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 2

ER -