Topological organization of the "small-world" visual attention network in children with attention deficit/hyperactivity disorder (ADHD)

Shugao Xia, John J. Foxe, Ariane E. Sroubek, Craig A. Branch, Xiaobo Li

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed childhood psychiatric disorder. Disrupted sustained attention is one of the most significant behavioral impairments in this disorder. We mapped systems-level topological properties of the neural network responsible for sustained attention during a visual sustained task, on the premise that strong associations between anomalies in network features and clinical measures of ADHD would emerge. Methods: Graph theoretic techniques (GTT) and bivariate network-based statistics (NBS) were applied to fMRI data from 22 children with ADHD combined-type and 22 age-matched neurotypicals, to evaluate the topological and nodal-pairing features in the functional brain networks. Correlation testing for relationships between network properties and clinical measures were then performed. Results: The visual attention network showed significantly reduced local-efficiency and nodal-efficiency in frontal and occipital regions in ADHD. Measures of degree and between-centrality pointed to hyper-functioning in anterior cingulate cortex and hypo-functioning in orbito-frontal, middle-occipital, superior-temporal, supra-central, and supra-marginal gyri in ADHD. NBS demonstrated significantly reduced pair-wise connectivity in an inner-network, encompassing right parietal and temporal lobes and left occipital lobe, in the ADHD group. Conclusions: These data suggest that atypical topological features of the visual attention network contribute to classic ADHD symptomatology, and may underlie the inattentiveness and hyperactivity/impulsivity that are characteristics of this syndrome.

Original languageEnglish (US)
Article number162
JournalFrontiers in Human Neuroscience
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 20 2014

Fingerprint

Attention Deficit Disorder with Hyperactivity
Occipital Lobe
Parietal Lobe
Impulsive Behavior
Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Psychiatry
Magnetic Resonance Imaging
Brain

Keywords

  • Adhd
  • Attention
  • FMRI
  • Functional connectivity
  • Graph theoretic techniques
  • Network-based statistic
  • Small world network

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Topological organization of the "small-world" visual attention network in children with attention deficit/hyperactivity disorder (ADHD). / Xia, Shugao; Foxe, John J.; Sroubek, Ariane E.; Branch, Craig A.; Li, Xiaobo.

In: Frontiers in Human Neuroscience, Vol. 8, No. MAR, 162, 20.03.2014.

Research output: Contribution to journalArticle

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