Topographic study of Alzheimer's neurofibrillary changes

A personal perspective

Asao Hirano, Maki Iida

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Argentophilic neurofibrillary tangles were described in the cerebral cortex of Alzheimer's disease and later in the pigmented neurons in the brain stem of postencephalitic parkinsonism. In 1961, wide distribution of Alzheimer's neurofibrillary tangles in the central nervous system was observed in endemic fatal neurodegenerative diseases affecting the native Chamorro population on Guam: amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Abundant neurofibrillary tangles were found but no senile plaques. A topographic analysis of tangles in cases inGuam and at Montefiore were published in 1962 [23]. Thereafter, Alzheimer's neurofibrillary changes were documented in various areas of the nervous system of many other diseases. This communication is a brief review of the topographic investigation of Alzheimer's neurofibrillary changes. Occurrence of tangles in various conditions seems to indicate that various pathological agents can induce tangles. On the other hand, Alzheimer's neurofibrillary tangles, in general, show a rather striking predilection to affect particular neurons in the involved regions.

Original languageEnglish (US)
Title of host publicationAlzheimer's Disease: A Century of Scientific and Clinical Research
PublisherIOS Press
Pages53-60
Number of pages8
ISBN (Print)9781586036195
StatePublished - Jul 2006

Fingerprint

Neurofibrillary Tangles
Postencephalitic Parkinson Disease
Guam
Neurons
Amyloid Plaques
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Cerebral Cortex
Nervous System
Brain Stem
Alzheimer Disease
Central Nervous System
Population

Keywords

  • Alzheimer's disease
  • Alzheimer's neurofibrillary changes
  • Parkinsonism-dementia complex on Guam
  • Topographic study

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hirano, A., & Iida, M. (2006). Topographic study of Alzheimer's neurofibrillary changes: A personal perspective. In Alzheimer's Disease: A Century of Scientific and Clinical Research (pp. 53-60). IOS Press.

Topographic study of Alzheimer's neurofibrillary changes : A personal perspective. / Hirano, Asao; Iida, Maki.

Alzheimer's Disease: A Century of Scientific and Clinical Research. IOS Press, 2006. p. 53-60.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hirano, A & Iida, M 2006, Topographic study of Alzheimer's neurofibrillary changes: A personal perspective. in Alzheimer's Disease: A Century of Scientific and Clinical Research. IOS Press, pp. 53-60.
Hirano A, Iida M. Topographic study of Alzheimer's neurofibrillary changes: A personal perspective. In Alzheimer's Disease: A Century of Scientific and Clinical Research. IOS Press. 2006. p. 53-60
Hirano, Asao ; Iida, Maki. / Topographic study of Alzheimer's neurofibrillary changes : A personal perspective. Alzheimer's Disease: A Century of Scientific and Clinical Research. IOS Press, 2006. pp. 53-60
@inbook{fecc45df735a4047803d87825a2d7ef8,
title = "Topographic study of Alzheimer's neurofibrillary changes: A personal perspective",
abstract = "Argentophilic neurofibrillary tangles were described in the cerebral cortex of Alzheimer's disease and later in the pigmented neurons in the brain stem of postencephalitic parkinsonism. In 1961, wide distribution of Alzheimer's neurofibrillary tangles in the central nervous system was observed in endemic fatal neurodegenerative diseases affecting the native Chamorro population on Guam: amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Abundant neurofibrillary tangles were found but no senile plaques. A topographic analysis of tangles in cases inGuam and at Montefiore were published in 1962 [23]. Thereafter, Alzheimer's neurofibrillary changes were documented in various areas of the nervous system of many other diseases. This communication is a brief review of the topographic investigation of Alzheimer's neurofibrillary changes. Occurrence of tangles in various conditions seems to indicate that various pathological agents can induce tangles. On the other hand, Alzheimer's neurofibrillary tangles, in general, show a rather striking predilection to affect particular neurons in the involved regions.",
keywords = "Alzheimer's disease, Alzheimer's neurofibrillary changes, Parkinsonism-dementia complex on Guam, Topographic study",
author = "Asao Hirano and Maki Iida",
year = "2006",
month = "7",
language = "English (US)",
isbn = "9781586036195",
pages = "53--60",
booktitle = "Alzheimer's Disease: A Century of Scientific and Clinical Research",
publisher = "IOS Press",

}

TY - CHAP

T1 - Topographic study of Alzheimer's neurofibrillary changes

T2 - A personal perspective

AU - Hirano, Asao

AU - Iida, Maki

PY - 2006/7

Y1 - 2006/7

N2 - Argentophilic neurofibrillary tangles were described in the cerebral cortex of Alzheimer's disease and later in the pigmented neurons in the brain stem of postencephalitic parkinsonism. In 1961, wide distribution of Alzheimer's neurofibrillary tangles in the central nervous system was observed in endemic fatal neurodegenerative diseases affecting the native Chamorro population on Guam: amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Abundant neurofibrillary tangles were found but no senile plaques. A topographic analysis of tangles in cases inGuam and at Montefiore were published in 1962 [23]. Thereafter, Alzheimer's neurofibrillary changes were documented in various areas of the nervous system of many other diseases. This communication is a brief review of the topographic investigation of Alzheimer's neurofibrillary changes. Occurrence of tangles in various conditions seems to indicate that various pathological agents can induce tangles. On the other hand, Alzheimer's neurofibrillary tangles, in general, show a rather striking predilection to affect particular neurons in the involved regions.

AB - Argentophilic neurofibrillary tangles were described in the cerebral cortex of Alzheimer's disease and later in the pigmented neurons in the brain stem of postencephalitic parkinsonism. In 1961, wide distribution of Alzheimer's neurofibrillary tangles in the central nervous system was observed in endemic fatal neurodegenerative diseases affecting the native Chamorro population on Guam: amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Abundant neurofibrillary tangles were found but no senile plaques. A topographic analysis of tangles in cases inGuam and at Montefiore were published in 1962 [23]. Thereafter, Alzheimer's neurofibrillary changes were documented in various areas of the nervous system of many other diseases. This communication is a brief review of the topographic investigation of Alzheimer's neurofibrillary changes. Occurrence of tangles in various conditions seems to indicate that various pathological agents can induce tangles. On the other hand, Alzheimer's neurofibrillary tangles, in general, show a rather striking predilection to affect particular neurons in the involved regions.

KW - Alzheimer's disease

KW - Alzheimer's neurofibrillary changes

KW - Parkinsonism-dementia complex on Guam

KW - Topographic study

UR - http://www.scopus.com/inward/record.url?scp=84880188656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880188656&partnerID=8YFLogxK

M3 - Chapter

SN - 9781586036195

SP - 53

EP - 60

BT - Alzheimer's Disease: A Century of Scientific and Clinical Research

PB - IOS Press

ER -