Topographic study of Alzheimer's neurofibrillary changes: A personal perspective

Asao Hirano, Maki Iida

Research output: Contribution to journalArticle

Abstract

Argentophilic neurofibrillary tangles were described in the cerebral cortex of Alzheimer's disease and later in the pigmented neurons in the brain stem of postencephalitic parkinsonism. In 1961, wide distribution of Alzheimer's neurofibrillary tangles in the central nervous system was observed in endemic fatal neurodegenerative diseases affecting the native Chamorro population on Guam: amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Abundant neurofibrillary tangles were found but no senile plaques. A topographic analysis of tangles in cases inGuam and at Montefiore were published in 1962 [23]. Thereafter, Alzheimer's neurofibrillary changes were documented in various areas of the nervous system of many other diseases. This communication is a brief review of the topographic investigation of Alzheimer's neurofibrillary changes. Occurrence of tangles in various conditions seems to indicate that various pathological agents can induce tangles. On the other hand, Alzheimer's neurofibrillary tangles, in general, show a rather striking predilection to affect particular neurons in the involved regions.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalJournal of Alzheimer's Disease
Volume9
Issue numberSUPPL. 3
StatePublished - 2006

Fingerprint

Neurofibrillary Tangles
Postencephalitic Parkinson Disease
Guam
Neurons
Amyloid Plaques
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Cerebral Cortex
Nervous System
Brain Stem
Alzheimer Disease
Central Nervous System
Population

Keywords

  • Alzheimer's disease
  • Alzheimer's neurofibrillary changes
  • Parkinsonism-dementia complex on Guam
  • Topographic study

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Topographic study of Alzheimer's neurofibrillary changes : A personal perspective. / Hirano, Asao; Iida, Maki.

In: Journal of Alzheimer's Disease, Vol. 9, No. SUPPL. 3, 2006, p. 53-60.

Research output: Contribution to journalArticle

Hirano, Asao ; Iida, Maki. / Topographic study of Alzheimer's neurofibrillary changes : A personal perspective. In: Journal of Alzheimer's Disease. 2006 ; Vol. 9, No. SUPPL. 3. pp. 53-60.
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