Abstract
We report a case of treatment-resistant obsessive-compulsive disorder (OCD) that was successfully treated with a pharmacological augmentation of topiramate plus paroxetine. The patient, a 45-year-old woman, was on a stable dose of paroxetine (40 mg/day) when she was started on topiramate (up to 150 mg/day). After 9 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the evaluation scales (Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression Scale). Our case suggests that topiramate might be beneficial in augmentation with selective serotonin reuptake inhibitors in patients with treatment-resistant OCD, although further investigations are warranted to confirm our findings.
Original language | English (US) |
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Pages (from-to) | 189-191 |
Number of pages | 3 |
Journal | International Clinical Psychopharmacology |
Volume | 21 |
Issue number | 3 |
DOIs | |
State | Published - May 2006 |
Externally published | Yes |
Keywords
- Augmentation
- Obsessive-compulsive disorder
- Paroxetine
- Topiramate
- Treatment-resistant
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)