Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis

J. B. Oldenburg, D. C. Gritz, P. J. McDonnell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1789) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.

Original languageEnglish (US)
Pages (from-to)1142-1144
Number of pages3
JournalArchives of Ophthalmology
Volume108
Issue number8
StatePublished - 1990
Externally publishedYes

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Ultraviolet Rays
Keratitis
Rabbits
Radiation
octylmethoxycinnamate
Incidence

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Oldenburg, J. B., Gritz, D. C., & McDonnell, P. J. (1990). Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis. Archives of Ophthalmology, 108(8), 1142-1144.

Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis. / Oldenburg, J. B.; Gritz, D. C.; McDonnell, P. J.

In: Archives of Ophthalmology, Vol. 108, No. 8, 1990, p. 1142-1144.

Research output: Contribution to journalArticle

Oldenburg, JB, Gritz, DC & McDonnell, PJ 1990, 'Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis', Archives of Ophthalmology, vol. 108, no. 8, pp. 1142-1144.
Oldenburg, J. B. ; Gritz, D. C. ; McDonnell, P. J. / Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis. In: Archives of Ophthalmology. 1990 ; Vol. 108, No. 8. pp. 1142-1144.
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