Topical Ultraviolet Light-Absorbing Chromophore Protects Against Experimental Photokeratitis

J. Brent Oldenburg; David C. Gritz; Peter J. McDonnell

doi:10.1001/archopht.1990.01070100098042

Topical Ultraviolet Light-Absorbing Chromophore Protects Against Experimental Photokeratitis

J. Brent Oldenburg, David C. Gritz, Peter J. McDonnell

Ophthalmology & Visual Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1789) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.

Original language	English (US)
Pages (from-to)	1142-1144
Number of pages	3
Journal	Archives of Ophthalmology
Volume	108
Issue number	8
DOIs	https://doi.org/10.1001/archopht.1990.01070100098042
State	Published - Aug 1990

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1990.01070100098042

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abstract = "Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1789) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.",

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AU - McDonnell, Peter J.

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Topical Ultraviolet Light-Absorbing Chromophore Protects Against Experimental Photokeratitis

Abstract

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