Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model

D. C. Gritz, P. J. McDonnell, T. Y. Lee, D. Tang-Liu, B. B. Hubbard, A. Gwon

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Abstract

Ofloxacin, a new quinolone antibiotic with a broad spectrum of activity, is very effective against Pseudomonas aeruginosa in vitro. Its effectiveness was studied in a rabbit model of tobramycin-sensitive P. aeruginosa. Treatment groups received either vehicle, tobramycin 0.3%, or ofloxacin 0.3%. Twelve hours of treatment decreased the bacterial counts from a mean of 2.2 ± 0.7 x 106 colony forming units (cfu) per cornea in the vehicle group to means of 513 ± 670 and 435 ± 524 cfu in the tobramycin and ofloxacin groups, respectively. This decrease in bacterial counts was statistically significant (p = 0.001 for tobramycin and ofloxacin each compared with control, p = 0.86 for tobramycin compared with ofloxacin). After seven days, all antibiotic-treated corneas were sterile and the epithelial defects healed at comparable rates. Aqueous humor drug levels were higher in infected eyes without an intact epithelium (p = 0.02); in eyes with intact epithelium, concentrations of ofloxacin were higher than were those of tobramycin (p = 0.002). In this animal model, ofloxacin proved to be an effective antibiotic with no evidence of toxicity.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalCornea
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Ophthalmology

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    Gritz, D. C., McDonnell, P. J., Lee, T. Y., Tang-Liu, D., Hubbard, B. B., & Gwon, A. (1992). Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model. Cornea, 11(2), 143-147. https://doi.org/10.1097/00003226-199203000-00008