Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis

Breanne Mordorski, Caroline Barcelos Costa-Orlandi, Ludmila M. Baltazar, Leandro J. Carreño, Angelo Landriscina, Jamie Rosen, Mahantesh Navati, Maria Jose Soares Mendes-Giannini, Joel M. Friedman, Joshua D. Nosanchuk, Adam J. Friedman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. To address this, we investigated topical nitric oxide-releasing nanoparticles (NO-np), which have been used against superficial fungal infections and bacterial abscesses. In addition to enhanced penetration and permeation conferred by nanoparticles, nitric oxide, a broad-spectrum multi-mechanistic antimicrobial agent, offers decreased likelihood of resistance development. In the current study, NO-np inhibited Trichophyton rubrum in vitro, as well as in a murine model of dermal dermatophytosis. In mice, NO-np reduced fungal burden after three days, with complete clearance after seven. Furthermore, NO-np decreased tissue IL-2, 6, 10 and TNFα, indicating earlier attenuation of the host inflammatory response and decreased tissue morbidity. Thus, topical NO-np represent an attractive alternative to systemic therapy against dermal T. rubrum infection.

Original languageEnglish (US)
Pages (from-to)2267-2270
Number of pages4
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number7
DOIs
StatePublished - Oct 2017

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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