Topical anti-inflammatory agents in an animal model of microbial keratitis

D. C. Gritz, T. Y. Lee, S. Kwitko, P. J. McDonnell

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Topical steroids potentiate Pseudomonas keratitis in the absence of concomitant antibiotic therapy. The effects of other anti-inflammatory agents on microbial keratitis are unknown, but if these agents do not intensify the infection, they may be useful in the initial management of microbial keratitis by limiting ulceration and thus the size of the resultant corneal scar. In rabbit models of untreated Pseudomonas keratitis and pneumococcal keratitis, topical 1% prednisolone phosphate, 0.03% flurbiprofen sodium, and vehicle were applied hourly. In cases of Pseudomonas keratitis, prednisolone worsened the clinical disease, and flurbiprofen further worsened the disease. When combined with effective antibiotic therapy, neither anti-inflammatory agent worsened the disease. In pneumococcal keratitis, neither anti-inflammatory agent worsened the disease. Topical anti-inflammatory agents should be used with caution in cases of microbial keratitis at least until effective antibiotic therapy has been instituted.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalArchives of Ophthalmology
Volume108
Issue number7
StatePublished - 1990
Externally publishedYes

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Keratitis
Anti-Inflammatory Agents
Animal Models
Pseudomonas
Flurbiprofen
Anti-Bacterial Agents
Prednisolone
Therapeutics
Steroids
Rabbits
Infection

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Gritz, D. C., Lee, T. Y., Kwitko, S., & McDonnell, P. J. (1990). Topical anti-inflammatory agents in an animal model of microbial keratitis. Archives of Ophthalmology, 108(7), 1001-1005.

Topical anti-inflammatory agents in an animal model of microbial keratitis. / Gritz, D. C.; Lee, T. Y.; Kwitko, S.; McDonnell, P. J.

In: Archives of Ophthalmology, Vol. 108, No. 7, 1990, p. 1001-1005.

Research output: Contribution to journalArticle

Gritz, DC, Lee, TY, Kwitko, S & McDonnell, PJ 1990, 'Topical anti-inflammatory agents in an animal model of microbial keratitis', Archives of Ophthalmology, vol. 108, no. 7, pp. 1001-1005.
Gritz DC, Lee TY, Kwitko S, McDonnell PJ. Topical anti-inflammatory agents in an animal model of microbial keratitis. Archives of Ophthalmology. 1990;108(7):1001-1005.
Gritz, D. C. ; Lee, T. Y. ; Kwitko, S. ; McDonnell, P. J. / Topical anti-inflammatory agents in an animal model of microbial keratitis. In: Archives of Ophthalmology. 1990 ; Vol. 108, No. 7. pp. 1001-1005.
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