To the nucleus with proteomics

Bryen A. Jordan, Edward B. Ziff

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.

Original languageEnglish (US)
Title of host publicationTranscriptional Regulation by Neuronal Activity: To the Nucleus and Back
PublisherSpringer US
Pages27-50
Number of pages24
ISBN (Print)9780387736099, 9780387736082
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Proteomics
Synapses
Post-Synaptic Density
Proteins
Intercellular Junctions
Calmodulin
Computational Biology
RNA Splicing Factors

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Jordan, B. A., & Ziff, E. B. (2008). To the nucleus with proteomics. In Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back (pp. 27-50). Springer US. https://doi.org/10.1007/978-0-387-73609-9_2

To the nucleus with proteomics. / Jordan, Bryen A.; Ziff, Edward B.

Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back. Springer US, 2008. p. 27-50.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jordan, BA & Ziff, EB 2008, To the nucleus with proteomics. in Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back. Springer US, pp. 27-50. https://doi.org/10.1007/978-0-387-73609-9_2
Jordan BA, Ziff EB. To the nucleus with proteomics. In Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back. Springer US. 2008. p. 27-50 https://doi.org/10.1007/978-0-387-73609-9_2
Jordan, Bryen A. ; Ziff, Edward B. / To the nucleus with proteomics. Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back. Springer US, 2008. pp. 27-50
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