Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Marit Sletmoen, Thomas A. Gerken, Bjørn T. Stokke, Joy Burchell, Curtis F. Brewer

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalGlycobiology
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2018

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Neoplasm Antigens
Carbohydrates
Polysaccharides
Mucins
Neoplasms
Carcinogenesis

Keywords

  • carbohydrate tumor antigens
  • carbohydrate-carbohydrate interactions
  • mechanism of action
  • Neu5Gc-GM3
  • optical tweezers
  • Tn and STn cancer antigens

ASJC Scopus subject areas

  • Biochemistry

Cite this

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions. / Sletmoen, Marit; Gerken, Thomas A.; Stokke, Bjørn T.; Burchell, Joy; Brewer, Curtis F.

In: Glycobiology, Vol. 28, No. 7, 01.07.2018, p. 437-442.

Research output: Contribution to journalReview article

Sletmoen, Marit ; Gerken, Thomas A. ; Stokke, Bjørn T. ; Burchell, Joy ; Brewer, Curtis F. / Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions. In: Glycobiology. 2018 ; Vol. 28, No. 7. pp. 437-442.
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AU - Gerken, Thomas A.

AU - Stokke, Bjørn T.

AU - Burchell, Joy

AU - Brewer, Curtis F.

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