Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Marit Sletmoen, Thomas A. Gerken, Bjørn T. Stokke, Joy Burchell, C. Fred Brewer

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalGlycobiology
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2018

Keywords

  • Neu5Gc-GM3
  • Tn and STn cancer antigens
  • carbohydrate tumor antigens
  • carbohydrate-carbohydrate interactions
  • mechanism of action
  • optical tweezers

ASJC Scopus subject areas

  • Biochemistry

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