T‐lymphocyte subpopulation changes during hemolysis in glucose‐6‐phosphate dehydrogenase (G6PD)‐deficient children

G. Schilirò, C. Minniti, A. Sciotto, A. Bellino, A. Russo

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Lymphocyte subpopulations were studied by means of sheep red blood cell (SRC)‐rosetting technique and OKT11, OKT3, OKT4, and OKT8 monoclonal antibodies in ten Sicilian glucose‐6‐phosphate dehydrogenase‐deficient children during the hemolytic crisis due to fava bean ingestion. The number of SRC‐rosetting lymphocytes was significantly reduced, while the number of OKT3‐positive cells was normal. An inversion of the OKT4/OKT8 ratio was observed, due to a decrease of OKT4‐positive cells and an increase of OKT8‐positive cells. All these abnormalities reverted to normal in the four children studied after recovery.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalAmerican Journal of Hematology
Volume21
Issue number2
DOIs
StatePublished - Feb 1986
Externally publishedYes

    Fingerprint

Keywords

  • G6PD deficiency
  • T‐lymphocyte subpopulations
  • hemolysis
  • monoclonal antibodies

ASJC Scopus subject areas

  • Hematology

Cite this