Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis

J. L. Hook, S. M. Arcasoy, D. Zemmel, Matthew N. Bartels, S. M. Kawut, D. J. Lederer

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The supplemental oxygen flow rate is a common bedside measure of gas exchange impairment. We aimed to determine whether a titrated oxygen requirement (TOR) predicted mortality in idiopathic pulmonary fibrosis (IPF). We examined 104 adults with IPF enrolled in a prospective cohort study and a validation cohort of 151 adults with a variety of interstitial lung diseases (ILDs). The TOR was defined as the lowest oxygen flow rate required to maintain an oxyhaemoglobin saturation of 96% while standing. Cox proportional hazards models and time-dependent receiver operating characteristic curves were used to examine survival time. A higher TOR was associated with a greater mortality rate independent of forced vital capacity and 6-min walk test results in IPF (adjusted hazard ratio (per 1 L·min -1) 1.16, 95% CI 1.06-1.27). The TOR was at least as accurate as pulmonary function and 6-min walk testing at predicting 1-yr mortality. Findings were similar in other ILDs. The TOR is a simple, inexpensive bedside measurement that aids prognostication in IPF. Copyright

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalEuropean Respiratory Journal
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Fingerprint

Idiopathic Pulmonary Fibrosis
Oxygen
Interstitial Lung Diseases
Mortality
Oxyhemoglobins
Vital Capacity
Proportional Hazards Models
ROC Curve
Cohort Studies
Gases
Prospective Studies
Lung

Keywords

  • Idiopathic pulmonary fibrosis
  • Interstitial lung diseases
  • Outcome prediction
  • Pulmonary fibrosis
  • Pulmonary gas exchange

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. / Hook, J. L.; Arcasoy, S. M.; Zemmel, D.; Bartels, Matthew N.; Kawut, S. M.; Lederer, D. J.

In: European Respiratory Journal, Vol. 39, No. 2, 01.02.2012, p. 359-365.

Research output: Contribution to journalArticle

Hook, J. L. ; Arcasoy, S. M. ; Zemmel, D. ; Bartels, Matthew N. ; Kawut, S. M. ; Lederer, D. J. / Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. In: European Respiratory Journal. 2012 ; Vol. 39, No. 2. pp. 359-365.
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