Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences

C. A. Rosen, W. A. Haseltine, Jack Lenz, R. Ruprecht, M. W. Cloyd

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Here we show that the tissue specificity of murine retrovirus infections is determined by the long terminal repeat (LTR) of an otherwise isogenic set of viruses. The isogenic viruses used for this study contain the coding gag, pol, and env genes of the avirulent Akv virus. Recombinant viruses that contain the LTR of a virus that induces T-cell leukemia lymphoma preferentially infect T lymphocytes. Viruses that carry the LTR of a virus that induces erythroleukemia preferentially infect non-T lymphoblastoid cell lines in the marrow and spleen. The Akv virus itself displays no tissue preference for hematopoietic cells. These experiments suggest that retroviruses that carry appropriate enhancer-promoters can be used to infect selectively specific target cells in animals.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalJournal of Virology
Volume55
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Murine leukemia virus
Murine Leukemia Viruses
terminal repeat sequences
Terminal Repeat Sequences
Virus Diseases
Viruses
viruses
infection
Retroviridae
T-lymphocytes
Retroviridae Infections
pol Genes
gag Genes
env Genes
T-Cell Leukemia
Leukemia, Erythroblastic, Acute
Organ Specificity
tissues
T-Cell Lymphoma
lymphoma

ASJC Scopus subject areas

  • Immunology

Cite this

Rosen, C. A., Haseltine, W. A., Lenz, J., Ruprecht, R., & Cloyd, M. W. (1985). Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. Journal of Virology, 55(3), 862-866.

Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. / Rosen, C. A.; Haseltine, W. A.; Lenz, Jack; Ruprecht, R.; Cloyd, M. W.

In: Journal of Virology, Vol. 55, No. 3, 1985, p. 862-866.

Research output: Contribution to journalArticle

Rosen, CA, Haseltine, WA, Lenz, J, Ruprecht, R & Cloyd, MW 1985, 'Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences', Journal of Virology, vol. 55, no. 3, pp. 862-866.
Rosen, C. A. ; Haseltine, W. A. ; Lenz, Jack ; Ruprecht, R. ; Cloyd, M. W. / Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. In: Journal of Virology. 1985 ; Vol. 55, No. 3. pp. 862-866.
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