Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences

C. A. Rosen, W. A. Haseltine, J. Lenz, R. Ruprecht, M. W. Cloyd

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Abstract

Here we show that the tissue specificity of murine retrovirus infections is determined by the long terminal repeat (LTR) of an otherwise isogenic set of viruses. The isogenic viruses used for this study contain the coding gag, pol, and env genes of the avirulent Akv virus. Recombinant viruses that contain the LTR of a virus that induces T-cell leukemia lymphoma preferentially infect T lymphocytes. Viruses that carry the LTR of a virus that induces erythroleukemia preferentially infect non-T lymphoblastoid cell lines in the marrow and spleen. The Akv virus itself displays no tissue preference for hematopoietic cells. These experiments suggest that retroviruses that carry appropriate enhancer-promoters can be used to infect selectively specific target cells in animals.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalJournal of virology
Volume55
Issue number3
Publication statusPublished - Dec 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Rosen, C. A., Haseltine, W. A., Lenz, J., Ruprecht, R., & Cloyd, M. W. (1985). Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. Journal of virology, 55(3), 862-866.