Tissue-Engineered Urinary Conduits

Max Kates, Anirudha Singh, Hotaka Matsui, Gary D. Steinberg, Norm D. Smith, Mark P. Schoenberg, Trinity J. Bivalacqua

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

The role of tissue engineering in the cystectomy population rests on the principle of sparing healthy intestinal tissue while replacing diseased bladder. Over the last 25 years advances in cell biology and material science have improved the quality and durability of bladder replacement in animals. The neo-urinary conduit ([NUC]-Tengion) employs autologous fat smooth muscle cells which are seeded onto synthetic, biodegradable scaffolds. This seeded construct is then implanted in the patient and purportedly regenerates native urinary tissue to serve as a passive channel connecting the ureters to the skin surface. Preclinical animal studies as well as the first phase I human trial implanting the NUC are reviewed. While the ultimate goal of creating a durable, effective, tissue-engineered conduit is still in its infancy, important technical and experimental strides have been made.

Original languageEnglish (US)
JournalCurrent urology reports
Volume16
Issue number3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Cystectomy population
  • Phase I human trial implanting
  • Tissue engineering
  • Urinary conduits

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Kates, M., Singh, A., Matsui, H., Steinberg, G. D., Smith, N. D., Schoenberg, M. P., & Bivalacqua, T. J. (2015). Tissue-Engineered Urinary Conduits. Current urology reports, 16(3). https://doi.org/10.1007/s11934-015-0480-3