Tissue Doppler-derived diastolic myocardial velocities are abnormal in pediatric cardiac transplant recipients in the absence of endomyocardial rejection

Sebastian Strigl, Rose Hardy, Julie S. Glickstein, Daphne T. Hsu, Linda J. Addonizio, Jacqueline M. Lamour, Ashwin Prakash

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The aim of this study was to evaluate diastolic function in pediatric cardiac transplant recipients free of acute rejection using tissue Doppler. E′ and A′ velocities at the mitral, septal, and tricuspid annuli in 31 pediatric heart transplant recipients free of acute rejection were compared with 28 controls and with previously published pediatric normative data. E′ velocities were lower in the transplant group at the mitral (0.13 ± 0.04 vs. 0.2 ± 0.04 m/s, p < 0.0001), septal (0.1 ± 0.03 vs. 0.14 ± 0.03 m/s, p = 0.001), and tricuspid annuli (0.1 ± 0.04 vs. 0.17 ± 0.04 m/s, p < 0.0001). A′ velocities were also lower in the transplant group at the septal (0.04 ± 0.01 vs. 0.06 ± 0.01 m/s, p = 0.001) and tricuspid annuli (0.06 ± 0.02 vs. 0.1 ± 0.03 m/s, p < 0.00001). E′ and A′ were abnormally low at the mitral annulus in 31% and 13%, septal annulus in 50% and 21%, and tricuspid annulus in 63% and 36% of the subjects, respectively. Abnormalities in tissue Doppler-derived diastolic myocardial velocities are common in pediatric cardiac transplant recipients free of acute rejection.

Original languageEnglish (US)
Pages (from-to)749-754
Number of pages6
JournalPediatric Cardiology
Volume29
Issue number4
DOIs
StatePublished - Jul 2008

Keywords

  • Cardiac transplantation
  • Children
  • Tissue Doppler

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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