TY - JOUR
T1 - Tissue Doppler-derived diastolic myocardial velocities are abnormal in pediatric cardiac transplant recipients in the absence of endomyocardial rejection
AU - Strigl, Sebastian
AU - Hardy, Rose
AU - Glickstein, Julie S.
AU - Hsu, Daphne T.
AU - Addonizio, Linda J.
AU - Lamour, Jacqueline M.
AU - Prakash, Ashwin
PY - 2008/7
Y1 - 2008/7
N2 - The aim of this study was to evaluate diastolic function in pediatric cardiac transplant recipients free of acute rejection using tissue Doppler. E′ and A′ velocities at the mitral, septal, and tricuspid annuli in 31 pediatric heart transplant recipients free of acute rejection were compared with 28 controls and with previously published pediatric normative data. E′ velocities were lower in the transplant group at the mitral (0.13 ± 0.04 vs. 0.2 ± 0.04 m/s, p < 0.0001), septal (0.1 ± 0.03 vs. 0.14 ± 0.03 m/s, p = 0.001), and tricuspid annuli (0.1 ± 0.04 vs. 0.17 ± 0.04 m/s, p < 0.0001). A′ velocities were also lower in the transplant group at the septal (0.04 ± 0.01 vs. 0.06 ± 0.01 m/s, p = 0.001) and tricuspid annuli (0.06 ± 0.02 vs. 0.1 ± 0.03 m/s, p < 0.00001). E′ and A′ were abnormally low at the mitral annulus in 31% and 13%, septal annulus in 50% and 21%, and tricuspid annulus in 63% and 36% of the subjects, respectively. Abnormalities in tissue Doppler-derived diastolic myocardial velocities are common in pediatric cardiac transplant recipients free of acute rejection.
AB - The aim of this study was to evaluate diastolic function in pediatric cardiac transplant recipients free of acute rejection using tissue Doppler. E′ and A′ velocities at the mitral, septal, and tricuspid annuli in 31 pediatric heart transplant recipients free of acute rejection were compared with 28 controls and with previously published pediatric normative data. E′ velocities were lower in the transplant group at the mitral (0.13 ± 0.04 vs. 0.2 ± 0.04 m/s, p < 0.0001), septal (0.1 ± 0.03 vs. 0.14 ± 0.03 m/s, p = 0.001), and tricuspid annuli (0.1 ± 0.04 vs. 0.17 ± 0.04 m/s, p < 0.0001). A′ velocities were also lower in the transplant group at the septal (0.04 ± 0.01 vs. 0.06 ± 0.01 m/s, p = 0.001) and tricuspid annuli (0.06 ± 0.02 vs. 0.1 ± 0.03 m/s, p < 0.00001). E′ and A′ were abnormally low at the mitral annulus in 31% and 13%, septal annulus in 50% and 21%, and tricuspid annulus in 63% and 36% of the subjects, respectively. Abnormalities in tissue Doppler-derived diastolic myocardial velocities are common in pediatric cardiac transplant recipients free of acute rejection.
KW - Cardiac transplantation
KW - Children
KW - Tissue Doppler
UR - http://www.scopus.com/inward/record.url?scp=46749094303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46749094303&partnerID=8YFLogxK
U2 - 10.1007/s00246-007-9188-6
DO - 10.1007/s00246-007-9188-6
M3 - Article
C2 - 18176771
AN - SCOPUS:46749094303
SN - 0172-0643
VL - 29
SP - 749
EP - 754
JO - Pediatric Cardiology
JF - Pediatric Cardiology
IS - 4
ER -