Abstract
A time course analysis was performed to identify the sites of formation and timing of appearance of polytropic recombinant viruses following infection of NIH/Swiss mice with the murine retrovirus SL3-3 murine leukemia virus (SL3) or with a weakly pathogenic mutant termed SL3ΔMyb5. The results indicated that (i) polytropic recombinant viruses occur initially in the thymus of SL3-infected animals, (ii) the timing of appearance of polytropic recombinants in bone marrow is not consistent with their participation in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postinoculation, and (iii) the efficient generation of recombinant virus is correlated with efficient tumor induction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 522-526 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 75 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Tissue distribution and timing of appearance of polytropic envelope recombinants during infection with SL3-3 murine leukemia virus or its weakly pathogenic SL3ΔMyb5 mutant. / Rulli, K.; Lobelle-Rich, P. A.; Trubetskoy, A.; Lenz, Jack; Levy, L. S.
In: Journal of Virology, Vol. 75, No. 1, 2001, p. 522-526.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tissue distribution and timing of appearance of polytropic envelope recombinants during infection with SL3-3 murine leukemia virus or its weakly pathogenic SL3ΔMyb5 mutant
AU - Rulli, K.
AU - Lobelle-Rich, P. A.
AU - Trubetskoy, A.
AU - Lenz, Jack
AU - Levy, L. S.
PY - 2001
Y1 - 2001
N2 - A time course analysis was performed to identify the sites of formation and timing of appearance of polytropic recombinant viruses following infection of NIH/Swiss mice with the murine retrovirus SL3-3 murine leukemia virus (SL3) or with a weakly pathogenic mutant termed SL3ΔMyb5. The results indicated that (i) polytropic recombinant viruses occur initially in the thymus of SL3-infected animals, (ii) the timing of appearance of polytropic recombinants in bone marrow is not consistent with their participation in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postinoculation, and (iii) the efficient generation of recombinant virus is correlated with efficient tumor induction.
AB - A time course analysis was performed to identify the sites of formation and timing of appearance of polytropic recombinant viruses following infection of NIH/Swiss mice with the murine retrovirus SL3-3 murine leukemia virus (SL3) or with a weakly pathogenic mutant termed SL3ΔMyb5. The results indicated that (i) polytropic recombinant viruses occur initially in the thymus of SL3-infected animals, (ii) the timing of appearance of polytropic recombinants in bone marrow is not consistent with their participation in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postinoculation, and (iii) the efficient generation of recombinant virus is correlated with efficient tumor induction.
UR - http://www.scopus.com/inward/record.url?scp=0034751130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034751130&partnerID=8YFLogxK
U2 - 10.1128/JVI.75.1.522-526.2001
DO - 10.1128/JVI.75.1.522-526.2001
M3 - Article
VL - 75
SP - 522
EP - 526
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 1
ER -