Tissue distribution and timing of appearance of polytropic envelope recombinants during infection with SL3-3 murine leukemia virus or its weakly pathogenic SL3ΔMyb5 mutant

K. Rulli, P. A. Lobelle-Rich, A. Trubetskoy, Jack Lenz, L. S. Levy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A time course analysis was performed to identify the sites of formation and timing of appearance of polytropic recombinant viruses following infection of NIH/Swiss mice with the murine retrovirus SL3-3 murine leukemia virus (SL3) or with a weakly pathogenic mutant termed SL3ΔMyb5. The results indicated that (i) polytropic recombinant viruses occur initially in the thymus of SL3-infected animals, (ii) the timing of appearance of polytropic recombinants in bone marrow is not consistent with their participation in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postinoculation, and (iii) the efficient generation of recombinant virus is correlated with efficient tumor induction.

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalJournal of Virology
Volume75
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Murine leukemia virus
Murine Leukemia Viruses
tissue distribution
Tissue Distribution
Viruses
viruses
mutants
Retroviridae
Virus Diseases
Infection
infection
Thymus Gland
Neoplasms
neoplasms
Bone Marrow
mice
bone marrow
animals
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Tissue distribution and timing of appearance of polytropic envelope recombinants during infection with SL3-3 murine leukemia virus or its weakly pathogenic SL3ΔMyb5 mutant. / Rulli, K.; Lobelle-Rich, P. A.; Trubetskoy, A.; Lenz, Jack; Levy, L. S.

In: Journal of Virology, Vol. 75, No. 1, 2001, p. 522-526.

Research output: Contribution to journalArticle

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