Timing of onset of antidepressant response with fluoxetine treatment

A. A. Nierenberg, A. H. Farabaugh, Jonathan E. Alpert, J. Gordon, J. J. Worthington, J. F. Rosenbaum, M. Fava

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess the time until onset of antidepressant response with fluoxetine treatment. Method: The authors evaluated 182 outpatients with major depression who had a sustained acute response to fluoxetine treatment. The outpatients received 8 weeks of treatment with 20 mg/day of fluoxetine and were assessed biweekly with the 17-item Hamilton Depression Rating Scale. The onset of response was defined as a 30% decrease in score on the Hamilton depression scale that persisted and led to a 50% decrease by week 8. The Kaplan-Meier product limit and Cox regression analysis were used to model the relationship between relevant variables and time until onset of response. Results: The authors found that at weeks 2, 4, and 6, the probabilities of having an onset of response (for responders) were 55.5%, 24.7%, and 9.3%, respectively. The cumulative probabilities of onset of response at each time point were 55.5%, 80.2%, and 89.5%. Neither demographics nor clinical characteristics of depression predicted time until initial response. Conclusions: These data suggest that more than half of eventual responders to fluoxetine treatment at 8 weeks start to respond by week 2; over 75% start to respond by week 4. Conversely, the lack of onset of response at 4-6 weeks was associated with about a 73%-88% chance that patients would not have an onset of response by 8 weeks.

Original languageEnglish (US)
Pages (from-to)1423-1428
Number of pages6
JournalAmerican Journal of Psychiatry
Volume157
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

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Fluoxetine
Antidepressive Agents
Outpatients
Therapeutics
Regression Analysis
Demography

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Nierenberg, A. A., Farabaugh, A. H., Alpert, J. E., Gordon, J., Worthington, J. J., Rosenbaum, J. F., & Fava, M. (2000). Timing of onset of antidepressant response with fluoxetine treatment. American Journal of Psychiatry, 157(9), 1423-1428. https://doi.org/10.1176/appi.ajp.157.9.1423

Timing of onset of antidepressant response with fluoxetine treatment. / Nierenberg, A. A.; Farabaugh, A. H.; Alpert, Jonathan E.; Gordon, J.; Worthington, J. J.; Rosenbaum, J. F.; Fava, M.

In: American Journal of Psychiatry, Vol. 157, No. 9, 2000, p. 1423-1428.

Research output: Contribution to journalArticle

Nierenberg, AA, Farabaugh, AH, Alpert, JE, Gordon, J, Worthington, JJ, Rosenbaum, JF & Fava, M 2000, 'Timing of onset of antidepressant response with fluoxetine treatment', American Journal of Psychiatry, vol. 157, no. 9, pp. 1423-1428. https://doi.org/10.1176/appi.ajp.157.9.1423
Nierenberg AA, Farabaugh AH, Alpert JE, Gordon J, Worthington JJ, Rosenbaum JF et al. Timing of onset of antidepressant response with fluoxetine treatment. American Journal of Psychiatry. 2000;157(9):1423-1428. https://doi.org/10.1176/appi.ajp.157.9.1423
Nierenberg, A. A. ; Farabaugh, A. H. ; Alpert, Jonathan E. ; Gordon, J. ; Worthington, J. J. ; Rosenbaum, J. F. ; Fava, M. / Timing of onset of antidepressant response with fluoxetine treatment. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 9. pp. 1423-1428.
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