Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Eric Hollander, Lisa J. Cohen, Concetta DeCaria, Jihad B. Saoud, Dan J. Stein, Thomas B. Cooper, Nazrul N. Islam, Michael R. Liebowitz, Donald F. Klein

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

Original languageEnglish (US)
Pages (from-to)407-413
Number of pages7
JournalBiological Psychiatry
Volume34
Issue number6
DOIs
StatePublished - Sep 15 1993
Externally publishedYes

Keywords

  • M-CPP
  • cortisol
  • fenfluramine
  • obsessive-compulsive disorder
  • prolactin
  • serotonin

ASJC Scopus subject areas

  • Biological Psychiatry

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    Hollander, E., Cohen, L. J., DeCaria, C., Saoud, J. B., Stein, D. J., Cooper, T. B., Islam, N. N., Liebowitz, M. R., & Klein, D. F. (1993). Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD. Biological Psychiatry, 34(6), 407-413. https://doi.org/10.1016/0006-3223(93)90186-H