### Abstract

Hypothesis: The time from onset of contraction to dP/dt(max), td, is suggested as an index of contractility in the catheterization laboratory. Methods: We studied 22 normal patients and 18 patients with myocardial failure in the catheterization laboratory. The two groups were completely separated on the t(d)-heart rate (HR) plane. In the normal patients. HR = 73 ± 19 beats/min, t(d) = 73 ± 11 ms, and an inverse linear relation t(d) = 109-0.49 X HR (p<0.001) exist. In the patients with myocardial failure, despite significantly higher HR than in normal patients (HR = 93 ± 14 beat/min) (p < 0.001 t(d) to paradoxically increased (t(d) = 89 ±11 ms, p<0.0001). Conclusions: These findings support a mathematical analysis of the left ventricular pressure (LVP) during isovolumic contraction in the time domain which shows that to and (dP/dt)/P reflect the time-dependent aspects of contraction and, hence, decrease with increasing contractility. This study shows that t(d), at any given HR, is a reliable index of contractility. Thus, a ready-to-use t(d)-HR plot containing a well-based separation line can provide a reliable and simple method for determining contractility in the catheterization laboratory by examining whether a patient's to value at any HR is below (normal) or above (impaired contractility) the separation line.

Original language | English (US) |
---|---|

Pages (from-to) | 397-403 |

Number of pages | 7 |

Journal | Clinical Cardiology |

Volume | 19 |

Issue number | 5 |

State | Published - May 1996 |

### Fingerprint

### Keywords

- cardiac catheterization
- cardiac inotropism
- heart contractility
- left ventricular function
- myocardial contraction
- myocardial diseases

### ASJC Scopus subject areas

- Cardiology and Cardiovascular Medicine

### Cite this

*Clinical Cardiology*,

*19*(5), 397-403.

**Time to dP/dt(max), a useful index for evaluation of contractility in the catheterization laboratory.** / Adler, David; Monrad, E. Scott; Hess, Otto M.; Krayenbuehl, Hans P.; Sonnenblick, Edmund H.

Research output: Contribution to journal › Article

*Clinical Cardiology*, vol. 19, no. 5, pp. 397-403.

}

TY - JOUR

T1 - Time to dP/dt(max), a useful index for evaluation of contractility in the catheterization laboratory

AU - Adler, David

AU - Monrad, E. Scott

AU - Hess, Otto M.

AU - Krayenbuehl, Hans P.

AU - Sonnenblick, Edmund H.

PY - 1996/5

Y1 - 1996/5

N2 - Hypothesis: The time from onset of contraction to dP/dt(max), td, is suggested as an index of contractility in the catheterization laboratory. Methods: We studied 22 normal patients and 18 patients with myocardial failure in the catheterization laboratory. The two groups were completely separated on the t(d)-heart rate (HR) plane. In the normal patients. HR = 73 ± 19 beats/min, t(d) = 73 ± 11 ms, and an inverse linear relation t(d) = 109-0.49 X HR (p<0.001) exist. In the patients with myocardial failure, despite significantly higher HR than in normal patients (HR = 93 ± 14 beat/min) (p < 0.001 t(d) to paradoxically increased (t(d) = 89 ±11 ms, p<0.0001). Conclusions: These findings support a mathematical analysis of the left ventricular pressure (LVP) during isovolumic contraction in the time domain which shows that to and (dP/dt)/P reflect the time-dependent aspects of contraction and, hence, decrease with increasing contractility. This study shows that t(d), at any given HR, is a reliable index of contractility. Thus, a ready-to-use t(d)-HR plot containing a well-based separation line can provide a reliable and simple method for determining contractility in the catheterization laboratory by examining whether a patient's to value at any HR is below (normal) or above (impaired contractility) the separation line.

AB - Hypothesis: The time from onset of contraction to dP/dt(max), td, is suggested as an index of contractility in the catheterization laboratory. Methods: We studied 22 normal patients and 18 patients with myocardial failure in the catheterization laboratory. The two groups were completely separated on the t(d)-heart rate (HR) plane. In the normal patients. HR = 73 ± 19 beats/min, t(d) = 73 ± 11 ms, and an inverse linear relation t(d) = 109-0.49 X HR (p<0.001) exist. In the patients with myocardial failure, despite significantly higher HR than in normal patients (HR = 93 ± 14 beat/min) (p < 0.001 t(d) to paradoxically increased (t(d) = 89 ±11 ms, p<0.0001). Conclusions: These findings support a mathematical analysis of the left ventricular pressure (LVP) during isovolumic contraction in the time domain which shows that to and (dP/dt)/P reflect the time-dependent aspects of contraction and, hence, decrease with increasing contractility. This study shows that t(d), at any given HR, is a reliable index of contractility. Thus, a ready-to-use t(d)-HR plot containing a well-based separation line can provide a reliable and simple method for determining contractility in the catheterization laboratory by examining whether a patient's to value at any HR is below (normal) or above (impaired contractility) the separation line.

KW - cardiac catheterization

KW - cardiac inotropism

KW - heart contractility

KW - left ventricular function

KW - myocardial contraction

KW - myocardial diseases

UR - http://www.scopus.com/inward/record.url?scp=0029790241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029790241&partnerID=8YFLogxK

M3 - Article

C2 - 8723599

AN - SCOPUS:0029790241

VL - 19

SP - 397

EP - 403

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 5

ER -