Time course of miniature postsynaptic potentials at the Mauthner fiber giant synapse of the hatchetfish

J. W. Day, W. D. Huse, Michael V. L. Bennett

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The hatchetfish Mauthner fiber is presynaptic to 8-14 large myelinated axons in the medulla; the large ('giant') synapses formed by these fibers appear to be nicotinic cholinergic. Miniature postsynaptic potentials (mPSPs) were recorded from single identified synapses. The mPSPs were averaged to more accurately determine their shape; the rise time was approximately 70 μs, and the fall usually was biphasic with time constants of decay for the two phases of 280 and 800 μs. In 25% of the records analyzed a third, slow tail of decay was seen which had an average decay constant of 4.2 ms. The biphasic decay of mPSPs largely accounts for the similar shape of the postsynaptic current following a presynaptic impulse, which is described in the accompanying paper.

Original languageEnglish (US)
Pages (from-to)115-128
Number of pages14
JournalBrain Research
Volume325
Issue number1-2
DOIs
StatePublished - Jan 28 1985

Fingerprint

Miniature Postsynaptic Potentials
Synapses
Synaptic Potentials
Cholinergic Agents
Axons

Keywords

  • acetylcholine
  • hatchetfish
  • Mauthner fiber
  • miniature postsynaptic potential
  • synapse

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Time course of miniature postsynaptic potentials at the Mauthner fiber giant synapse of the hatchetfish. / Day, J. W.; Huse, W. D.; Bennett, Michael V. L.

In: Brain Research, Vol. 325, No. 1-2, 28.01.1985, p. 115-128.

Research output: Contribution to journalArticle

@article{5883ffa39b4c4531b7010a4e5179b6ff,
title = "Time course of miniature postsynaptic potentials at the Mauthner fiber giant synapse of the hatchetfish",
abstract = "The hatchetfish Mauthner fiber is presynaptic to 8-14 large myelinated axons in the medulla; the large ('giant') synapses formed by these fibers appear to be nicotinic cholinergic. Miniature postsynaptic potentials (mPSPs) were recorded from single identified synapses. The mPSPs were averaged to more accurately determine their shape; the rise time was approximately 70 μs, and the fall usually was biphasic with time constants of decay for the two phases of 280 and 800 μs. In 25{\%} of the records analyzed a third, slow tail of decay was seen which had an average decay constant of 4.2 ms. The biphasic decay of mPSPs largely accounts for the similar shape of the postsynaptic current following a presynaptic impulse, which is described in the accompanying paper.",
keywords = "acetylcholine, hatchetfish, Mauthner fiber, miniature postsynaptic potential, synapse",
author = "Day, {J. W.} and Huse, {W. D.} and Bennett, {Michael V. L.}",
year = "1985",
month = "1",
day = "28",
doi = "10.1016/0006-8993(85)90308-7",
language = "English (US)",
volume = "325",
pages = "115--128",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Time course of miniature postsynaptic potentials at the Mauthner fiber giant synapse of the hatchetfish

AU - Day, J. W.

AU - Huse, W. D.

AU - Bennett, Michael V. L.

PY - 1985/1/28

Y1 - 1985/1/28

N2 - The hatchetfish Mauthner fiber is presynaptic to 8-14 large myelinated axons in the medulla; the large ('giant') synapses formed by these fibers appear to be nicotinic cholinergic. Miniature postsynaptic potentials (mPSPs) were recorded from single identified synapses. The mPSPs were averaged to more accurately determine their shape; the rise time was approximately 70 μs, and the fall usually was biphasic with time constants of decay for the two phases of 280 and 800 μs. In 25% of the records analyzed a third, slow tail of decay was seen which had an average decay constant of 4.2 ms. The biphasic decay of mPSPs largely accounts for the similar shape of the postsynaptic current following a presynaptic impulse, which is described in the accompanying paper.

AB - The hatchetfish Mauthner fiber is presynaptic to 8-14 large myelinated axons in the medulla; the large ('giant') synapses formed by these fibers appear to be nicotinic cholinergic. Miniature postsynaptic potentials (mPSPs) were recorded from single identified synapses. The mPSPs were averaged to more accurately determine their shape; the rise time was approximately 70 μs, and the fall usually was biphasic with time constants of decay for the two phases of 280 and 800 μs. In 25% of the records analyzed a third, slow tail of decay was seen which had an average decay constant of 4.2 ms. The biphasic decay of mPSPs largely accounts for the similar shape of the postsynaptic current following a presynaptic impulse, which is described in the accompanying paper.

KW - acetylcholine

KW - hatchetfish

KW - Mauthner fiber

KW - miniature postsynaptic potential

KW - synapse

UR - http://www.scopus.com/inward/record.url?scp=0021991723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021991723&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)90308-7

DO - 10.1016/0006-8993(85)90308-7

M3 - Article

C2 - 2983824

AN - SCOPUS:0021991723

VL - 325

SP - 115

EP - 128

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -