Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery

James E. Haddow, Jane Cleary-Goldman, Monica R. McClain, Glenn E. Palomaki, Louis M. Neveux, Geralyn Lambert-Messerlian, Jacob A. Canick, Fergal D. Malone, T. Flint Porter, David A. Nyberg, Peter S. Bernstein, Mary E. D'Alton

Research output: Contribution to journalArticle

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Abstract

Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalObstetrics and Gynecology
Volume116
Issue number1
DOIs
StatePublished - Jul 2010
Externally publishedYes

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Thyroglobulin
Pregnancy
Antibodies
Thyroid Gland
Odds Ratio
Premature Birth
Second Pregnancy Trimester
Confidence Intervals
First Pregnancy Trimester
Aneuploidy
Pregnancy Outcome
Demography
Prospective Studies
Inflammation
Serum

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Haddow, J. E., Cleary-Goldman, J., McClain, M. R., Palomaki, G. E., Neveux, L. M., Lambert-Messerlian, G., ... D'Alton, M. E. (2010). Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. Obstetrics and Gynecology, 116(1), 58-62. https://doi.org/10.1097/AOG.0b013e3181e10b30

Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. / Haddow, James E.; Cleary-Goldman, Jane; McClain, Monica R.; Palomaki, Glenn E.; Neveux, Louis M.; Lambert-Messerlian, Geralyn; Canick, Jacob A.; Malone, Fergal D.; Porter, T. Flint; Nyberg, David A.; Bernstein, Peter S.; D'Alton, Mary E.

In: Obstetrics and Gynecology, Vol. 116, No. 1, 07.2010, p. 58-62.

Research output: Contribution to journalArticle

Haddow, JE, Cleary-Goldman, J, McClain, MR, Palomaki, GE, Neveux, LM, Lambert-Messerlian, G, Canick, JA, Malone, FD, Porter, TF, Nyberg, DA, Bernstein, PS & D'Alton, ME 2010, 'Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery', Obstetrics and Gynecology, vol. 116, no. 1, pp. 58-62. https://doi.org/10.1097/AOG.0b013e3181e10b30
Haddow JE, Cleary-Goldman J, McClain MR, Palomaki GE, Neveux LM, Lambert-Messerlian G et al. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. Obstetrics and Gynecology. 2010 Jul;116(1):58-62. https://doi.org/10.1097/AOG.0b013e3181e10b30
Haddow, James E. ; Cleary-Goldman, Jane ; McClain, Monica R. ; Palomaki, Glenn E. ; Neveux, Louis M. ; Lambert-Messerlian, Geralyn ; Canick, Jacob A. ; Malone, Fergal D. ; Porter, T. Flint ; Nyberg, David A. ; Bernstein, Peter S. ; D'Alton, Mary E. / Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 1. pp. 58-62.
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abstract = "Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5{\%} compared with 6.4{\%}, odds ratio [OR] 1.18; 95{\%} confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2{\%} compared with 0.7{\%}, OR 1.70; 95{\%} CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0{\%} compared with 1.2{\%}, OR 1.67; 95{\%} CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.",
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